Molecular Horizons - formerly the Centre for Medical and Molecular Bioscience (CMMB) - brings together a multidisciplinary team of chemists and biologists with a common interest in the molecular basis of disease and disease prevention from the School of Chemistry and School of Biological Sciences at the University of Wollongong.

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Papers from 2008

Intraspecific concerted evolution of the rDNA ITS1 in Anopheles farauti sensu stricto (Diptera: Culicidae) reveals recent patterns of population structure, Mark P. Dowton, James Bower, Nigel W. Beebe, and Robert D. Cooper

Population genetic structure, gene flow and sex-biased dispersal in frillneck lizards (Chlamydosaurus kingii), Mark P. Dowton, Thomas R. Madsen, and Beata Ujvari

Identification of forensically important Chrysomya (Diptera: Calliphoridae) species using the second ribosomal internal transcribed spacer (ITS2), Mark P. Dowton, James F. Wallman, and Leigh Nelson

The effect of small molecules in modulating the chaperone activity of alpha B-crystallin against ordered and disordered protein aggregation, Heath Ecroyd and John A. Carver

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Unraveling the mysteries of protein folding and misfolding, Heath Ecroyd and John A. Carver

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Dissociation from the oligomeric state is the rate-limiting step in fibril formation by kappa-casein, Heath Ecroyd, Tomas Koudelka, David Thorn, Danielle M. Williams, Glyn Devlin, Peter Hoffmann, and John A. Carver

"Synthesis, X-ray crystal structures, spectroscopy and electrochemistry of ruthenium(II) complexes of two chelating ligands containing [1,2,3]triazolo[1,5-a]pyridine subunits", Christopher Fitchett, F. Keene, Christopher Richardson, and Peter Steel

Protease activation of α2-Macroglobulin modulates a chaperone-like action with broad specificity, Katie French, Justin J. Yerbury, and Mark R. Wilson

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Opacity Factor Activity and Epithelial Cell Binding by the Serum Opacity Factor Protein of Streptococcus pyogenes Are Functionally Discrete, C. M. Gillen, H. S. Courtney, K. Schulze, M. Rohde, Mark R. Wilson, A. M. Timmer, C. A. Guzman, V. Nizet, G. S. Chhatwal, and Mark J. Walker

Long-term cardiac allograft survival across an MHC mismatch after "pruning" of alloreactive CD4 T cells, Min Hu, Debbie Watson, Geoff Y. Zhang, Nicole Graf, Yuan M. Wang, Mary Sartor, Brian Howden, Jeffery Fletcher, and Stephen I. Alexander

An assessment of an oil spill in Gladstone, Australia - impacts on intertidal areas at one month post-spill, Dianne F. Jolley, Felicity Melville, and L Andersen

Pyridines and their Benzo Derivatives: Synthesis, Paul A. Keller

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Oxidative coupling of indoles using thallium(III) trifluoroacetate, Paul A. Keller, N. R. Yepuri, M. J. Kelso, M. Mariani, B. W. Skelton, and A. H. White

Peptides and small molecules targeting the plasminogen activation system: Towards prophylactic anti-metastasis drugs for breast cancer, Michael J. Kelso, Phillip R. Clingan, Marie Ranson, and Joel Tyndall

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The key importance of soy isoflavone bioavailability to understanding health benefits, T. A. Larkin, William E. Price, and L. Astheimer

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Uptake and internalisation of copper by three marine microalgae: comparison of copper-sensitive and copper-tolerant species, Jacqueline L. Levy, Brad M. Angel, Jennifer L. Stauber, Wing L. Poon, Stuart L. Simpson, Shuk Han Cheng, and Dianne F. Jolley

Geometry and excitation energy fluctuations of NMA in aqueous solution with CHARMM, AMBER, OPLS, and GROMOS force fields: Implications for protein ultraviolet spectra simulation, Zhenyu Li, Haibo Yu, Wei Zhuang, and Shaul Mukamel

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Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation., Jason D. McArthur, F. C. McKay, V. Ramachandran, P. Shyam, Amanda J. Cork, Martina L. Sanderson-Smith, J. N. Cole, U. Ringdahl, U. Sjobring, M. Ranson, and Mark J. Walker

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Protein dynamics and stability: The distribution of atomic fluctuations in thermophilic and mesophilic dihydrofolate reductase derived using elastic incoherent neutron scattering, Lars Meinhold, David Clement, Moeava Tehei, Roy Daniel, John L. Finney, and Jeremy C. Smith

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Diastereoselective ritter reactions of chiral cyclic N-acyliminium ions: synthesis of pyrido- and pyrrolo [2,3-d] oxazoles and 4-hydroxy-5-N-acylaminopyrrolidines and 5-hydroxy-6-N-acylaminopiperidines, Ian R. Morgan, Arife Yazici, Stephen G. Pyne, and Brian W. Skelton

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Antimalarial Activity of 2,4-Diaminopyrimidines, J. Morgan, R. Haritakul, and Paul A. Keller

Systematic differences in membrane acyl composition associated with varying body mass in mammals occur in all phospholipid classes: an analysis of kidney and brain, Jessica R. Nealon, Stephen J. Blanksby, Todd W. Mitchell, and Paul Else

The identification and structural characterization of C7orf24 as y-glutamyl cyclotransferase: an essential enzyme in the y-glutamyl cycle, Aaron J. Oakley, Tetsuo Yamada, Dan Liu, Marjorie Coggan, Alan G. Clark, and Philip G. Board

Chromatin switching and transcriptional regulation in disease, Lezanne Ooi and Ian C. Wood

Identifying transcriptional regulatory regions using reporter genes and DNA-protein interactions by chromatin immunoprecipitation, Lezanne Ooi and Ian C. Wood

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Regulation of gene expression in the nervous system, Lezanne Ooi and Ian C. Wood

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The proofreading exonuclease subunit E of Escherichia coli DNA polymerase III is tethered to the polymerase subunit a via a flexible linker, Kiyoshi Ozawa, Slobodan Jergic, Ah-Young Park, Nicholas E. Dixon, and Gottfried Otting

Polymorphism of glutathione transferase Omega 1 in a population exposed to a high environmental arsenic burden, Leiliane Paiva, Richard Marcos, Amadeu Creus, Marjorie Coggan, Aaron J. Oakley, and Philip G. Board

Hydrolysis of the 5'-p-nitrophenyl ester of TMP by oligoribonucleases (ORN) from Escherichia coli, Mycobacterium smegmatis, and human, Ah-Young Park, Christopher M. Elvin, Samir M. Hamdan, Robert J. Wood, Nancy E. Liyou, Tamarind E. Hamwood, Phil A. Jennings, and Nicholas E. Dixon

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Clusterin interacts with paclitaxel and confer paclitaxel resistance in ovarian cancer, Dong Choon Park, Seung Geun Yeo, Mark R. Wilson, Justin J. Yerbury, Joseph Kwong, William R. Welch, Yang Kyu Choi, Michael J. Birrer, Samuel C. Mok, and Kwong-Kwok Wong

The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants, Lorien J. Parker, Sarah Ciccone, Louis C. Italiano, Alessandra Primavera, Aaron J. Oakley, Craig J. Morton, Nancy C. Hancock, Mario Lo Bello, and Michael W. Parker

Amino acids with an intermolecular proton bond as proton storage site in bacteriorhodopsin, Prasad Phatak, Nilanjan Ghosh, Haibo Yu, Qiang Cui, and Marcus Elstner

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On the electrodeposition of titanium in ionic liquids, William E. Price, Gordon G. Wallace, Douglas MacFarlane, S Z. El Abedin, A Y. Saad, F Endres, E M. Moustafa, P J. Newman, A Bund, and N Borissenko

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Exploiting the borono-Mannich reaction in bioactive alkaloid synthesis, Stephen G. Pyne, Christopher Au, Andrew S. Davis, Ian R. Morgan, Thunwadee Ritthiwigrom, and Arife Yazici

Diastereoselective borono-Mannich reactions on cyclic N-acyliminium ions, Stephen G. Pyne, Ian R. Morgan, and Arife Yazici

Chemotaxonomy of the peppergrass Lepidium coronopus (L.) Al-Shehbaz (syn. Coronopus squamatus) based on its volatile glucosinolate autolysis products, Niko Radulovic, Bojan Zlatkovic, Danielle Skropeta, and Radosav Palic´

Plasminogen activator inhibitor type 2 inhibits cell surface associated tissue plasminogen activator in vitro: potential receptor interactions, Marie Ranson, David Croucher, Darren Saunders, and Sergei A. Lobov

"4,5-Di(2-pyridyl)-1,2,3-triazolate: The elusive member of a family of bridging ligands that facilitate strong metal-metal interactions", Christopher Richardson, Christopher Fitchett, F. Keene, and Peter Steel

"Ruthenium(II) complexes of Chelating Ligands containing benzoxazole and benzothiazole subunits: Synthesis, X-ray crystallography, spectroscopy, and Electrochemistry", Christopher Richardson, F. Keene, and Peter Steel

Poly(T) Variation within mitochondrial protein-coding genes in Globodera (Nematoda: Heteroderidae), Angelique H. Riepsamen, Vivian C. Blok, Mark Phillips, Tracey Gibson, and Mark Dowton

Synthesis of (+)-uniflorine A: a structural reassignment and a configurational assignment, Thunwadee Ritthiwigrom and Stephen G. Pyne

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M protein mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate, Martina L. Sanderson-Smith, K. Dinkla, J. N. Cole, Amanda J. Cork, P. G. Maamary, Jason D. McArthur, G. S. Chhatwal, and Mark J. Walker

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The mitochondrial genome of the stingless bee Melipona bicolor (Hymenoptera, Apidae, Meliponini): Sequence, gene organization and a unique tRNA translocation event conserved across the tribe Meliponini, Daniela Silvestre, Mark P. Dowton, and Maria C. Arias

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Deep-sea Natural Products, Danielle Skropeta

"Host tissue damage" signal ATP impairs IL-12 and IFNy secretion in LPS stimulated whole human blood, Ronald Sluyter, Ralph Nanan, Anthony McLean, Stephen Huang, Brigitte Santner-Nanan, Marek Nalos, and Alamgir Khan

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Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids, Tanud Tanachatchairatana, John B. Bremner, Ratchanaporn Chokchaisiri, and Apichart Suksamrarn

Regioselective alkylation of pyrrole with 2-benzylidenemalononitriles catalyzed by Cu(OTf)2, Dilek Tasgin, Baris Temelli, Arife Yazici, Sertan Aytac, and Canan Unaleroglu

A mild and general method for the synthesis of 5-substituted and 5,5-disubstituted fulleroprolines, Rajeswari Thayumanavan, Bill C. Hawkins, Paul A. Keller, Stephen G. Pyne, and Graham E Ball

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Ozone induced dissociation: elucidation of double bond position within mass-selected lipid ions, Michael C. Thomas, Todd W. Mitchell, David G. Harman, Jane M. Deeley, Jessica R. Nealon, and Stephen J. Blanksby

Amyloid fibril formation by bovine milk alpha(s2)-casein occurs under physiological conditions yet is prevented by its natural counterpart, alpha(s1)-casein, David Thorn, Heath Ecroyd, M Sunde, Stephen Poon, and John A. Carver

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Do green and golden bell frogs Litoria aurea occupy habitats with fungicidal properties?, C G. Threlfall, Dianne F. Jolley, N Evershed, R L. Goldingay, and W A. Buttemer

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Comparison of mass spectrometry and other techniques for probing interactions between metal complexes and DNA, Thitima Urathamakul, Daniel J. Waller, Jennifer L. Beck, Janice Aldrich-Wright, and Stephen F. Ralph

Effect of statins on serum apolipoprotein J and paraoxonase-1 levels in patients with ischemic heart disease undergoing coronary angiography, Mark R. Wilson, Dimitri P. Mikhailidis, Maria V. Poulakou, Despina Perrea, Kosmas I. Paraskevas, Dimitrios C. Iliopoulos, Serafim I. Tsitsilonis, Ioannis S. Vlachos, and Sonia-Athena P. Karabina

Apolipoprotein J and Leptin Levels in Patients with Coronary Heart Disease, Mark R. Wilson, Dimitri P. Mikhailidis, Maria V. Poulakou, Christos Tsigris, Despina Perrea, Kosmas I. Paraskevas, and Dimitrios C. Iliopoulos

Carotenoid intake does not mediate a relationship between reactive oxygen species and bright colouration: experimental test in a lizard, Mark R. Wilson, Mats M. Olsson, Tobias O. Uller, Caroline Isaksson, and Beth Mott

Free Radicals run in lizard families, Mark R. Wilson, Mats M. Olsson, Tobias O. Uller, Caroline Isaksson, Beth Mott, Mo Healey, and Wanger Thomas

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Instant insight: think outside the cell, Mark R. Wilson and Justin J. Yerbury

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Extracellular chaperones and amyloids, Mark R. Wilson, Justin J. Yerbury, and Stephen Poon

Extensive conformational transitions are required to turn on ATP hydrolysis in myosin, Yang Yang, Haibo Yu, and Qiang Cui

Description of phosphate hydrolysis reactions with the self-consistent-charge density-functional-tight-binding (SCC-DFTB) theory: 1. Parameterization, Yang Yang, Haibo Yu, Darrin York, Marcus Elstner, and Qiang Cui

Papers from 2007

Chemical cross-linking of the chloroplast localized small heat-shock protein, Hsp21, and the model substrate citrate synthase, Emma Ahrman, W Lambert, Andrew Aquilina, C V Robinson, and CS Emanuelsson

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Effect of overlying water pH, dissolved oxygen, salinity and sediment disturbances on metal release and sequestration from metal contaminated marine sediments, Clare Atkinson, Dianne F. Jolley, and Stuart L. Simpson

The structure and function of a novel glycerophosphodiesterase from enterobacter aerogenes, Jennifer L. Beck, Stephen James Watt, David L. Ollis, Paul D. Carr, Colin J. Jackson, and Jian-Wei Liu

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The repressor element 1-silencing transcription factor regulates heart-specific gene expression using multiple chromatin-modifying complexes, Andrew J. Bingham, Lezanne Ooi, Lukasz Kozera, Edward White, and Ian C. Wood

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Some approaches to new antibacterial agents, John B. Bremner

Dual action-based approaches to antibacterial agents, John B. Bremner, Joseph Ambrus, and Siritron Samosorn

Dyeing of cotton and silk yarn with the extracted dye from the fruit hulls of Mongosteen, Garcinia Mangostana Linn, John B. Bremner, Montra Chairat, and K Chantrapromma

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Detection of Al(III) and Ga(III) complexes with morin by electrospray ionization mass spectrometry, John B. Bremner, Larry A. Hick, Jody Morgan, Saowanee Rattanaphani, Vichitr Rattanaphani, and C Septhum

An investigation into the Cytotoxicity and mode of action of some Novel N-Alkyl-Substituted Isatins, John B. Bremner, Stephen G. Pyne, Marie Ranson, Julie Locke, and Kara L. Perrow

In vitro cytotoxicity evaluation of some substituted isatin derivatives, John B. Bremner, Stephen G. Pyne, Marie Ranson, Julie Locke, and Kara L. Perrow

An adsorption and thermodynamic study of lac dyeing on cotton pretreated with chitosan, John B. Bremner, Saowanee Rattanaphani, Montra Chairat, and Vichitr Rattanaphani

An adsorption study of A1(III) ions onto chitosan, John B. Bremner, Saowanee Rattanaphani, Vichitr Rattanaphani, and C Septhum

A new palladium-mediated approach to 4-N-arylamino-1-butanols from peroxidic tetrahydrofuran and primary aromatic amines, John B. Bremner, Henry F Russell, S R. Thomas, M R. Lewis, Jennifer Bushell-Edghill, and Floyd Bates

Seven membered rings, John B. Bremner and Siritron Samosorn

Hetisine-type diterpenoid alkaloids from the Bhutanese medicinal plant Aconitum orochryseum, John B. Bremner, Siritron Samosorn, and Phurpa Wangchuk

Alanine metabolism, transport, and cycling in the brain, Stefan Broer, Angelika Broer, Jonas T. Hansen, William A. Bubb, Vladimir J. Balcar, Fatima A. Narasllah, Brett Garner, and Caroline Rae

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Anisotropic atomic motions in high-resolution protein crystallography molecular dynamics simulations, Conrad J. Burden and Aaron J. Oakley

Radiotracer studies of the antitumor metallocene molybdocene dichloride with biomolecules, Carolyn T. Dillon, Margaret M. Harding, Suzanne V. Smith, and Kate S. Campbell

Mitochondrial genomes in the Hymenoptera and their utility as phylogenetic markers, Mark P. Dowton and Lyda Castro

Phylogeny of the platygastroid wasps (Hymenoptera) based on sequences from the 18S rRNA, 28S rRNA and cytochrome oxidase I genes: implications for the evolution of the ovipositor system and host relationships, Mark P. Dowton, Lyda Castro, Andrew D Austin, Nicholas Murphy, and Danielle Carey

Sequence and characterization of six mitochondrial subgenomes from Globodera rostochiensis: multipartite structure is conserved amongst close nematode relatives, Mark P. Dowton, Tracey A. Gibson, and Vivian C. Blok

The mitochondrial subgenomes of the nematode Globodera pallida are mosaics: evidence of recombination in an animal mitochondrial genome, Mark P. Dowton, Tracey A. Gibson, Ian T. Riley, Vivian C. Blok, Mark S. Phillips, Duminda D. Kumarasinghe, and Gye-Won Hong

Mitochondrial DNA recombination in a free-ranging Australian lizard, Mark P. Dowton, Thomas R. Madsen, and Beata Ujvari

Using COI barcodes to identify forensically and medically important blowflies, Mark P. Dowton, James F. Wallman, and Leigh Nelson

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Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity, Heath W. Ecroyd, Sarah Meehan, J Horwitz, Andrew Aquilina, J L Benesch, C V Robinson, Cait MacPhee, and John Carver

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Aryl Nitro Reduction with Iron Powder or Stannous Chloride under Ultrasonic Irradiation, A. B. Gamble, James A. Garner, Christopher Gordon, S. M. J. O'Conner, and Paul A. Keller

Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression, Priyadarshini L. Ganesan, Stephen I. Alexander, Debbie Watson, Grant J. Logan, Geoff Y. Zhang, and Ian E. Alexander

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A New Methodology for the Simulation of Flexible Protein – Ligand Interactions, James A. Garner, John Deadman, David I. Rhodes, Renate Griffith, and Paul A. Keller

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Control of HIV Through the Inhibition of HIV-1 Integrase: A Medicinal Chemistry Perspective, Christopher Gordon, R. Griffith, and Paul A. Keller

Selectivity of an indolyl berberine derivative for tetrameric G-quadruplex DNA, Karina Gornall, Siritron Samosorn, Jihan H. Talib, John B. Bremner, and Jennifer L. Beck

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Reductive ring opening reactions of diphenyldihydrofullerenylpyrroles, William Hawkins, Paul A. Keller, and Stephen G. Pyne

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Corticotropin Releasing Hormone - a GPCR Drug Target, C. Hemley, A. McCluskey, and Paul A. Keller

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The unstructured C-terminus of the tau subunit of Escherichia coli DNA polymerase III holoenzyme is the site of interaction with the alpha subunit, Slobodan Jergic, Kiyoshi Ozawa, Neal K. Williams, Xun-Cheng Su, Daniel D. Scott, Samir M. Hamdan, Jeffrey A. Crowther, Gottfried Otting, and Nicholas E. Dixon

Assignment of paramagnetic 15N-HSQC spectra by heteronuclear exchange spectroscopy, Michael John, Madeleine J. Headlam, Nicholas E. Dixon, and Gottfried Otting

NMR detection of protein 15N-spins near paramagnetic lanthanide ions, Michael John, Ah-Young Park, Nicholas E. Dixon, and Gottfried Otting

Sequence-specific and stereospecific assignment of methyl groups using paramagnetic lanthanides, Michael John, Christophe Schmitz, Ah-Young Park, Nicholas E. Dixon, Thomas Huber, and Gottfried Otting

Inorganic nitrogen transformations in the treatment of landfill leachate with a high ammonium load: a case study, Dianne F. Jolley, S. R. Wilson, and Stephen Parkes

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Using calibration approaches to compensate for remaining matrix effects in quantitative liquid chromatography electrospray ionization multistage mass spectrometric analysis of phytoestrogens in aqueous environmental samples, Jinguo Kang, Larry A. Hick, and William E. Price

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A fragmentation study of isoflavones in negative electrospray ionization by MSn ion trap mass spectrometry and triple quadrupole mass spectrometry, Jinguo Kang, Larry A. Hick, and William E. Price

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Increased probiotic yogurt or resistant starch intake does not affect isoflavone bioavailability in subjects consuming a high soy diet, Theresa A. Larkin, William E. Price, and Lee B. Astheimer