Molecular Horizons - formerly the Centre for Medical and Molecular Bioscience (CMMB) - brings together a multidisciplinary team of chemists and biologists with a common interest in the molecular basis of disease and disease prevention from the School of Chemistry and School of Biological Sciences at the University of Wollongong.

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Papers from 2012

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Beyond barcoding: A mitochondrial genomics approach to molecular phylogenetics and diagnostics of blowflies (Diptera: Calliphoridae), Leigh Nelson, Christine L. Lambkin, Philip Batterham, James F. Wallman, Mark P. Dowton, Michael F. Whiting, David K. Yeates, and Stephen L. Cameron

Diagnostic-specific reductions in NMDA and mGlu5 glutamatergic receptors in schizophrenia, K A. Newell, N Jimenez, A E. Geddes, E Frank, T M. Du Bois, M Safadi, and Xu-Feng Huang

MGluR5 and NMDA receptor density are reduced in the dorsolateral prefrontal cortex of schizoaffective but not schizophrenia patients, Kelly Newell, Natalie Matosin, Elisabeth Frank, Chao Deng, and Xu-Feng Huang

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Molecular dynamics analysis of apolipoprotein-D - lipid hydroperoxide interactions: mechanism for selective oxidation of Met-93, Aaron J. Oakley, Surabhi Bhatia, Heath Ecroyd, and Brett Garner

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Polymorphic male color morphs visualized with steroids in monomorphic females: a tool for designing analysis of sex-limited trait inheritance, Mats M. Olsson, Mo Healey, Mark Wilson, and Michael Tobler

A significant component of ageing (dna damage) is reflected in fading breeding colors: an experimental test using innate antioxidant mimetics in painted dragon lizards, Mats M. Olsson, Michael Tobler, Mo Healey, Cecile Perrin, and Mark R. Wilson

New drugs under development for Alzheimer's disease, Lezanne Ooi, Kirubakaran Shanmugam, Mili Patel, Rachel Debono, and Gerald Munch

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High-yield cell-free protein synthesis for site-specific incorporation of unnatural amino acids at two sites, Kiyoshi Ozawa, Karin V. Loscha, Kekini V. Kuppan, Choy Theng Loh, Nicholas E. Dixon, and Gottfried Otting

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Influence of plantlet age and different soilless culture on acclimatization of Stemona curtisii Hook.f., Jiraporn Palee, Srisulak Dheeranupattana, Araya Jatisatienr, Sunanta Wangkarn, Pitchaya Mungkornasawakul, Stephen Pyne, Alison Ung, and Thanapat Sastraruji

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Isolation of tuberospironine A, a novel croomine derivative from Stemona tuberosa Lour., Pratiwi Pudjiastuti, Stephen G. Pyne, S Sugiyanto, and Wilford Lie

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Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms, Marie Ranson, Paula Berghofer, Kara L. Vine, Ivan Greguric, Rachael Shepherd, and Andrew Katsifis

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The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β, Ulrike K. Resenberger, Veronika Muller, Lisa M. Munter, Michael Baier, Gerd Multhaup, Mark R. Wilson, Konstanze F. Winklhofer, and Jorg Tatzelt

Dipyridyl β-diketonate complexes and their use as metalloligands in the formation of mixed-metal coordination networks, Christopher Richardson, Catherine Renouf, Mary F. Mahon, Andrew D. Burrows, Anna J. Warren, and John E. Warren

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Isolation, biological activities, and synthesis of the natural casuarines, Thunwadee Ritthiwigrom and Stephen G. Pyne

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Architecture and conservation of the bacterial DNA replication machinery, an underexploited drug target, Andrew Robinson, Rebecca J. Causer, and Nicholas E. Dixon

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Bacterial plasminogen receptors: mediators of a multifaceted relationship, Martina L. Sanderson-Smith, David M. P De Oliveira, Marie Ranson, and Jason D. McArthur

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Comparison of chemical constituents and antibacterial activities and antioxidant activities of the essential oil from leaves and fruits of Bridelia retusa (L.) A. Juss, D Sanseera, W Niwatananun, Saisunee Liawruangrath, Apiwat Baramee, Banyong Khantawa, Stephen G. Pyne, and Boonsom Liawruangrath

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Chemical composition and biological activities of the essential oil from leaves of Cleidion javanicum Bl, Duangsuree Sanseera, Wirat Niwatananun, Boonsom Liawruangrath, Saisunee Liawruangrath, Apiwat Baramee, and Stephen G. Pyne

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Antioxidant and anticancer activities from aerial parts of Acalypha indica Linn, Duangsuree Sanseera, Wirat Niwatananun, Boonsom Liawruangrath, Saisunee Liawruangrath, Apiwat Baramee, Kongkiat Trisuwan, and Stephen G. Pyne

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Synthesis of stemofoline analogues as acetylcholinesterase inhibitors, Kwankamol Sastraruji, Thanapat Sastraruji, Alison T. Ung, Renate Griffith, Araya Jatisatienr, and Stephen G. Pyne

Oxidation of acyclic alkenes and allyl and benzyl ethers with DIB/t-BuOOH/Mg(OAc)2, Thanapat Sastraruji, Stephen G. Pyne, and Alison T. Ung

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Is Seladin-1 really a selective Alzheimer's disease indicator?, Laura J. Sharpe, Jenny Wong, Brett Garner, Glenda M. Halliday, and Andrew J. Brown

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Synthesis of spirocyclic azacycles from the cyclization of furan tethered N-acyliminium ions, Sudhir R. Shengule, Anthony Willis, and Stephen G. Pyne

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DGT-induced copper flux predicts bioaccumulation and toxicity to bivalves in sediments with varying properties, Stuart L. Simpson, Heloise Yverneau, Anne Cremazy, Chad V. Jarolimek, Helen Price, and Dianne F. Jolley

Development of a high-performance liquid chromatography method for the simultaneous quantitation of glutathione and related thiols, Megan L. Steele, Lezanne Ooi, and Gerald Munch

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Model studies towards the total synthesis of the Stemona alkaloid 1-hydroxyprotostemonine: synthesis of ent-1-hydroxystemoamide, Nalivela Kumara Swamy and Stephen G. Pyne

Water in extremophiles [L'eau dans les extremophiles], Moeava Tehei

Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes, Domingo Mariano Adolfo Vera, Mark H. Haynes, Anthony R. Ball, Tianhong Dai, Christos Astrakas, Michael J. Kelso, Michael R. Hamblin, and George P. Tegos

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Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa, Phurpa Wangchuk, Paul A. Keller, Stephen G. Pyne, Thanapat Sastraruji, Malai Taweechotipatr, Roonglawan Rattanajak, Aunchalee Tonsomboon, and Sumalee Kamchonwongpaisan

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Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia, Phurpa Wangchuk, Paul A. Keller, Stephen G. Pyne, Anthony C. Willis, and Sumalee Kamchonwongpaisan

A quick, convenient and economical method for the reliable determination of methylglyoxal in millimolar concentrations: the N-acetyl-L-cysteine assay, Rebekka Wild, Lezanne Ooi, Velandai Srikanth, and Gerald Munch

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Roles of extracellular chaperones in amyloidosis, Amy R. Wyatt, Justin J. Yerbury, Rebecca A. Dabbs, and Mark R. Wilson

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Molecular mechanisms of K+ selectivity in Na/K pump, Haibo Yu, Ian Ratheal, Pablo Artigas, and Benoit Roux

Time-dependant alterations of hypothalamic energy regulatory network by olanzapine in rats, Q Zhang, M He, Hongqin Wang, J Lian, C Deng, and Xu-Feng Huang

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Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases, Huina Zhou, Joseph Brock, Dan Liu, Philip G. Board, and Aaron J. Oakley

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c-AMP dependent protein kinase A inhibitory activity of six algal extracts from South Eastern Australia and their fatty acid composition, Ana Zivanovic and Danielle Skropeta

Papers from 2011

Book review: Protein and Peptide Analysis by LC-MS Experimental Strategies, Jennifer Beck

Developments in electrospray ionization mass spectrometry of non-covalent DNA-ligand complexes, Jennifer L. Beck

Mass spectrometric studies of non-covalent binding interactions between metallointercalators and DNA, Jennifer L. Beck, Stephen F. Ralph, Thitima Urathamakul, and Jihan H. Talib

Enhanced molecular chaperone activity of the small heat-shock protein alphaB-cystallin following covalent immobilization onto a solid-phase support, V Bellotti, Heath W. Ecroyd, J A. Carver, H J Griesser, B Thierry, J G Shapter, S S Griesser, S Giorgetti, M R Nussio, J A Gerrard, and J Garvey

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Speciation of dissolved inorganic arsenic by diffusive gradients in thin films: selective binding of AsIII by 3-mercaptopropyl-functionalized silica gel, William W. Bennett, Peter R. Teasdale, Jarad G. Panther, David T. Welsh, and Dianne F. Jolley

Bacillus sp. CDB3 isolated from cattle dip-sites possesses two ars gene clusters, S. Bhat, Xuan Luo, Zhi-Qiang Xu, Li-Mei Liu, and Ren Zhang

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NanoESI mass spectrometry of Rubisco and Rubisco activase structures and their interactions with nucleotides and sugar phosphates, Michelle Blayney, Spencer M. Whitney, and Jennifer L. Beck

Synthesis of new benzo[b]thieno fused ring systems via transition metal-mediated cyclisations, John B. Bremner, Johana M. Mbere, Brian W. Skelton, and Allan White

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Synthesis and structural characterization of 1-[2-(5-Nitro-1H-indol-2-yl)phenyl]methylpyridinium chloride, John B. Bremner, Siritron Samosorn, Brian W. Skelton, and Allan White

Analysis of unsaturated lipids by ozone-induced dissociation, Stephen M. Brown, Todd Mitchell, and Stephen J. Blanksby

Using a genetically encoded fluorescent amino acid as a site-specific probe to detect binding of low-molecular-weight compounds, Susan E. Brown, Gottfried Otting, Zhi-Qiang Xu, Kiyoshi Ozawa, John G. Oakeshott, Gerhard Schenk, Chris Coppin, Isaac N. Ugwumba, Anthony J. Herlt, Kieran S. Hadler, and L De La Cruz

Dyeing of cotton yarn with the aqueous extract of the leaves of Eupatorium odoratum L. in Thailand and associated extract toxicity studies, Montra Chairat, U. Darumas, John B. Bremner, and P. Bangrak

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Lipid pathway alterations in Parkinson's Disease primary visual cortex, Danni Cheng, Andrew M. Jenner, Guanghou Shui, Wei Fun Cheong, Todd W. Mitchell, Jessica Nealon, Woojin Scott Kim, H McCann, Markus R. Wenk, Glenda Halliday, and Brett Garner

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Influence of Salicylic Acid on Alkaloid Production by Root Cultures of Stemona curtisii Hook. F., K. Chotikadachanarong, S. Dheeranupattana, Chaiwat Jatisatienr, S. Wangkarn, Pitchaya Mungkornasawakul, Stephen G. Pyne, Alison T. Ung, and Thanapat Sastraruji

Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid, Daniel R. Coghlan, John B. Bremner, Paul A. Keller, Stephen G. Pyne, Dorothy M. David, Kittiya Somphol, Dean Baylis, Jonathon Coates, John Deadman, David I. Rhodes, and A D Robertson

Synchrotron radiation x-ray spectroscopy for investigations of intracellular metallointercalators: x-ray fluorescence imaging and x-ray absorption spectroscopy, Carolyn T. Dillon

Improving a natural enzyme activity through incorporation of unnatural amino acids, Nicholas E. Dixon, David L. Ollis, Gottfried Otting, Zhi-Qiang Xu, Colin J. Jackson, Lewis N. Mander, Kiyoshi Ozawa, John G. Oakeshott, Gerhard Schenk, Chris Coppin, Sue Brown, Fernanda Ely, Isaac N. Ugwumba, Jee-Loon Foo, Anthony J. Herlt, and Matthew C. Taylor

The mitochondrial genome of the soybean cyst nematode, Heterodera glycines, Mark P. Dowton, Tracey A. Gibson, Jeffrey Barrett, Sergei Subbotin, David J. Chitwood, Janet Rowe, and Daniel Farrugia

NMR spectroscopy of 14-3-3zeta reveals a flexible C-terminal extension: differentiation of the chaperone and phosphoserine-binding activities of 14-3-3zeta, H Fu, Danielle M. Williams, Heath W. Ecroyd, John A. Carver, Lixin Zhang, Huanqin Dai, Joanna M. Woodcock, and K L. Goodwin

Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation, Brett Garner, A Brown, Hanna Appelqvist, C Nilsson, K Kagedal, and K Ollinger

Age-related lysosomal dysfunction: an unrecognized roadblock for cobalamin trafficking?, Brett Garner, Hua Zhao, and Ulf T. Brunk

Diet high in oat β-glucan activates the gut-hypothalamic (PYY3-36-NPY) axis and increases satiety in diet-induced obesity in mice, Xu-Feng Huang, Yinghua Yu, Eleanor Beck, Timothy South, Yulin Li, Marijka Batterham, Linda C. Tapsell, and Jiezhong Chen

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Potential control of risperidone-related cognitive deficits by adjunctive aripiprazole treatment, Chang-Hua Hu, Nagesh Pai, Xu-Feng Huang, and Chao Deng

Fatty acid uptake and incorporation into phospholipids in the rat lens., Jessica Hughes, Stephen J. Blanksby, Paul J. Donaldson, Roger J. W Truscott, and Todd Mitchell

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Nutritional ecology of essential fatty acids: an evolutionary perspective, Anthony J. Hulbert and Sarah K. Abbott

Investigation into the extension of the non-nucleoside reverse transcriptase binding pocket, Paul A. Keller, R Griffith, and T B. Dupree

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Revealing indigenous Indonesian traditional medicine: anti-infective agents, Paul A. Keller and Ari Satia Nugraha

Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of Phytochemicals and biological activities, Paul A. Keller, Stephen G. Pyne, Phurpa Wangchuk, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan, Aunchalee Tonsomboon, and M Taweechotipatr

Synthesis and hydrolytic evaluation of acid-labile imine-linked cytoxic isatin model systems, Lidia Matesic, Julie Locke, Kara L. Perrow, Marie Ranson, John B. Bremner, and Danielle Skropeta

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Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA), Hayden Matthews, Marie Ranson, Joel Tyndall, and Michael J. Kelso

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Isolation of linobiflavonoid, a novel biflavonoid from Linostoma pauciflorum Griff, Tawesin Navarat, Stephen G. Pyne, Uma Prawat, and Pittaya Tuntiwachwuttikul

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Glutathione transferases: a structural perspective, Aaron J. Oakley

Assessment of the gas phase stability of quadruplex DNA using travelling wave ion mobility mass spectrometry, Karina Porter and Jennifer L. Beck

A new isoflavone from Jacaranda obtusifolia H.B.K. ssp. rhombifolia (G.F.W. Meijer) gentry, Stephen G. Pyne, Boonsom Liawruangrath, Saisunee Liawruangrath, M Garson, S Khamsan, and A Teerawutkulrag

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Antimalarial, Anticancer, Antimicrobial activities and chemical constituents of essential oil from the aerial parts of Cyperus kyllingia Endl, Stephen G. Pyne, Boonsom Liawruangrath, Saisunee Liawruangrath, M Garson, S Khamsan, and A Teerawutkulrag

A comparative study of the essential oil from flowers and fruits of lepisanthes rubiginosa (Roxb.) Leenh, Stephen G. Pyne, Boonsom Liawruangrath, Saisunee Liawruangrath, A Teerawutkulrag, and J Chuangbunyat

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An unusually flexible expanded hexaamine cage and its CuII complexes: variable coordination modes and incomplete encapsulation, C-J Qin, Lloyd James, Jy D. Chartres, Leighton J. Alcock, Kimberley J. Davis, Anthony C. Willis, Alan M. Sargeson, Paul V. Bernhardt, and Stephen F. Ralph

Simultaneous monitoring of the transport of anions and cations across polypyrrole based composite membranes, Stephen F. Ralph, Marceline N. Akieh, Ari Ivaska, Johan Bobacka, R-M Latonen, and A Varga

Electrochemically controlled ion transport across polypyrrole/multi-walled carbon nanotube composite membranes, Stephen F. Ralph, Marceline N. Akieh, Ari Ivaska, Johan Bobacka, S Lindholm, and R-M Latonen

Copper(II) environments in some macrobicycle complexes at room and low temperatures: some novel binuclear chloro-bridged systems, Stephen F. Ralph, Alan M. Sargeson, Brian W. Skelton, Allan White, Jack M. Harrowfield, Lutz M. Engelhardt, Lisbeth Grondahl, and Alexandre N. Sobolev

Competition between coordination and hydrogen bonding in networks constructed using dipyridyl-1H-pyrazole ligands, Christopher Richardson, Andrew D. Burrows, V M. Pop, M I. Haja Mohideen, David J. Kelly, and M F. Mahon

Selective incorporation of functional dicarboxylates into zinc metal-organic frameworks, Christopher Richardson, Andrew D. Burrows, S P. Rigby, and L C. Fisher

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Poly(T) variation in heteroderid nematode mitochondrial genomes is predominantly an artefact of amplification, Angelique H. Riepsamen, Tracey A. Gibson, Janet Rowe, David J. Chitwood, Sergei Subbotin, and Mark P. Dowton

Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives, M Robertson, John B. Bremner, J Coates, John Deadman, Paul A. Keller, Stephen G. Pyne, Kittiya Somphol, and David I. Rhodes

Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury, Kirstin Rose, Lezanne Ooi, Carine Dalle, Brian Robertson, Ian C. Wood, and Nikita Gamper

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Ion selectivity in channels and transporters, Benoit Roux, Simon Berneche, Berhard Egwolf, Bogdan Lev, Sergei Y. Noskov, Christopher N. Rowley, and Haibo Yu

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Phytochemical Studies on Stemona aphylla: Isolation of a New Stemofoline Alkaloid and Six New Stemofurans, Thanapat Sastraruji, Sukanda Chaiyong, Araya Jatisatienr, Stephen G. Pyne, Alison T. Ung, and Wilford Lie

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Identification of phospholipids in human meibum by nano-electrospray ionisation tandem mass spectrometry, Jennifer T. Saville, Zhenjun Zhao, Mark DP Willcox, Manjula A. Ariyavidana, Stephen J. Blanksby, and Todd W. Mitchell

Mhp107 is a member of the multifunctional adhesin family of Mycoplasma hyopneumoniae, Lisa Seymour, Linda Falconer, Ania Deutscher, F. Chris Minion, Matthew P. Padula, Nicholas E. Dixon, Steven P Djordjevic, and Mark J. Walker

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Binding of the molecular chaperone alphaB-crystallin to Abeta amyloid fibrils inhibits fibril elongation, Sarah L. Shammas, Christopher A. Waudby, Shuyu Wang, Alexander K. Buell, Tuomas P. Knowles, Heath W. Ecroyd, Mark E. Welland, John A. Carver, Christopher M. Dobson, and Sarah Meehan

Exploring marine resources for new pharmaceutical applications, Danielle Skropeta

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Kinase inhibitors from marine sponges, Danielle Skropeta, Natalie Pastro, and Ana Zivanovic

The human P2X7 receptor and its role in innate immunity, Ronald Sluyter, Stephen J. Fuller, Leanne Stokes, James Wiley, and Ben J. Gu

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Significance of P2X7 Receptor Variants to Human Health and Disease, Ronald Sluyter and Leanne Stokes

Silver coordination networks and cages based on a semi-rigid bis(isoxazolyl) ligand, A Stevenson, Christopher Richardson, Paul R. Raithby, Andrew D. Burrows, David J. Kelly, and M F. Mahon

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Incorporation of chlorinated analogues of aliphatic amino acids during cell-free protein synthesis, Dannon J. Stigers, Zachary I. Watts, James E. Hennessy, Hye-Kyung Kim, Romeo Martini, Matthew C. Taylor, Kiyoshi Ozawa, Jeffrey W. Keillor, Nicholas E. Dixon, and Christopher J. Easton

Preclinical evaluation of novel, all-in-one formulations of 5-fluorouracil and folinic acid with reduced toxicity profiles, Tamantha Stutchbury, Kara Perrow, Julie Locke, Jeremy S. Chrisp, J. B. Bremner, P Clingan, and Marie Ranson

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Understanding the α-crystallin cell membrane conjunction, Shih-Ping Su, Jason D. McArthur, Michael G. Friedrich, Roger J. W Truscott, and J. A. Aquilina

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Stereoselective synthesis of two new trihydroxylated pyrrolidines using a meyer-schuster rearrangement, Nalivela K. Swamy and Stephen G. Pyne

Basal superoxide as a sexspecific immune constraint, Michael Tobler, Mo Healey, Mark R. Wilson, and Mats Olsson

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Corrigendum to ‘‘The chaperone action of bovine milk aS1- and aS2-caseins and their associated form aS-casein’’ [Arch. Biochem. Biophys. 510 (2011) 42–52], Teresa M. Treweek, David C. Thorn, William E. Price, and John A. Carver

Truncation, cross-linking and interaction of crystallins and intermediate filament proteins in the aging human lens, Roger J. Truscott, Jason D. McArthur, Andrew Aquilina, and Shi-Ping (Jim) Su

Tight binding of proteins to membranes from older human cells, Roger J. W Truscott, S. Comte-Walters, Z. Ablonczy, J. Schwacke, Yoke Berry, Anastasia Korlimbinis, M. Friedrich, and K. Schev

Synthesis of 2-acetyl-5-(1,2,3,4,5,6-hexahydroxyhexyl)thiazoles, Alison T. Ung, Stephen G. Pyne, Brian W. Skelton, A White, and G R. Jeoffreys