Diet high in oat β-glucan activates the gut-hypothalamic (PYY3-36-NPY) axis and increases satiety in diet-induced obesity in mice

Authors

Xu-Feng Huang, University of WollongongFollow
Yinghua Yu, University of WollongongFollow
Eleanor Beck, University of WollongongFollow
Timothy South, University of WollongongFollow
Yulin Li, University of WollongongFollow
Marijka Batterham, University of WollongongFollow
Linda C. Tapsell, University of WollongongFollow
Jiezhong Chen, University of WollongongFollow

RIS ID

37975

Publication Details

Huang, X., Yu, Y., Beck, E., South, T., Li, Y., Batterham, M., Tapsell, L. C. & Chen, J. 2011, 'Diet high in oat β-glucan activates the gut-hypothalamic (PYY3-36-NPY) axis and increases satiety in diet-induced obesity in mice', Molecular Nutrition and Food Research, vol. 55, no. 7, pp. 1118-1121.

Abstract

This study tested the effects of (1-3),(1-4) b-D-glucan from oats, on activation of the guthypothalamic (PYY3–36-NPY) axis, satiety, and weight loss in diet-induced obesity (DIO) mice. DIO mice were fed standard lab chow diets or varied doses of b-glucan for 6 weeks. Energy intake, satiety, body weight changes and peptide Y-Y3-36 (PYY3-36) were measured together with a satiety test and measurement of neuropeptide Y (NPY) mRNA expression in the hypothalamic arcuate nucleus (Arc). The average energy intake (-13%, po0.05) and body weight gain was lower with increasing b-glucan over 6 wk with acute suppression of energy intake over 4 h. The highest b-glucan diet significantly increased plasma PYY3-36, with suppression of Arc NPY mRNA.