Molecular Horizons - formerly the Centre for Medical and Molecular Bioscience (CMMB) - brings together a multidisciplinary team of chemists and biologists with a common interest in the molecular basis of disease and disease prevention from the School of Chemistry and School of Biological Sciences at the University of Wollongong.

Follow

Papers from 2010

PDF

Sensitivity of the female rat to olanzapine-induced weight gain - far from the clinic?, Katrina Weston-Green, Xu-Feng Huang, and Chao Deng

PDF

Identification of human plasma proteins as major clients for the extracellular chaperone clusterin, Amy R. Wyatt and Mark R. Wilson

Clinical comparison of Bur- and laser-prepared minimally invasive occlusal resin composite restorations: Two-year follow-up, Arife Yazici, M Baseren, and J Gorucu

PDF

Protein chemistry of amyloid fibrils and chaperones: implications for amyloid formation and disease, Justin J. Yerbury and Janet R. Kumita

PDF

Extracellular chaperones modulate the effects of Alzheimer's patient cerebrospinal fluid on A beta(1-42) toxicity and uptake , Justin J. Yerbury and Mark R. Wilson

PDF

What you need to know about selenium, Terry Young, Keith Finley, William Adams, John Besser, William D. Hopkins, Dianne F. Jolley, Eugenia McNaughton, Theresa S. Presser, D. Patrick Shaw, and Jason Unrine

PDF

A combined experimental and theoretical study of ion solvation in liquid N-methylacetamide, Haibo Yu, Christopher L. Mazzanti, Troy W. Whitfield, Roger E. Koeppe II, Olaf S. Andersen, and Benoit Roux

Two mechanisms of ion selectivity in protein binding sites, Haibo Yu, Sergei Noskov, and Benoit Roux

Protonation of key acidic residues is critical for the K+-selectivity of the Na/K pump, Haibo Yu, Ian Ratheal, Pablo Artigas, and Benoit Roux

Simulating monovalent and divalent ions in aqueous solution using a drude polarizable force field, Haibo Yu; Troy Whitfield; Edward Harder; Guillaume Lamoureux; Igor Vorobyov; Victor Anisimov; Alexander MacKerell, Jr.; and Benoit Roux

Mechanochemical coupling in molecular motors: insights from molecular simulations of the myosin motor domain, Haibo Yu, Yang Yang, Liang Ma, and Qiang Cui

Papers from 2009

Substrate-induced Assembly of Methanococcoides burtonii D-Ribulose-1,5-bisphosphate Carboxylase/Oxygenase Dimers into Decamers, Hernan Alonso, Michelle Blayney, Jennifer L. Beck, and Spencer Whitney

PDF

The major toxin from the Australian Common Brown Snake is a hexamer with unusual gas-phase dissociation properties, Andrew Aquilina

Semisynthesis and biological activity of stemofoline alkaloids, Morwenna C. Baird, Stephen G. Pyne, Alison T. Ung, Wilford Lie, Thanapat Sastraruji, Araya Jatisatienr, Chaiwat Jatisatienr, Srisulak Dheeranupattana, Jaturong Lowlam, and Sukanya Boonchalermkit

PDF

The synthesis of carbon linked bis-benzylisoquinolines using Mizoroki–Heck and Sonagashira coupling reactions, Uta Batenburg-Nguyen, Alison T. Ung, and Stephen G. Pyne

PDF

Increases in peptide Y-Y levels following oat β-glucan ingestion are dose-dependent in overweight adults, Eleanor J. Beck, Linda C. Tapsell, Marijka J. Batterham, Susan M. Tosh, and Xu-Feng Huang

Oat β-glucan increases postprandial cholecystokinin levels, decreases insulin response and extends subjective satiety in overweight subjects, Eleanor J. Beck, Susan M. Tosh, Marijka J. Batterham, Linda C. Tapsell, and Xu-Feng Huang

Does the metal influence non-covalent binding of complexes to DNA?, Jennifer L. Beck, Stephen F. Ralph, Carolyn T. Dillon, David G. Harman, Janice Aldrich-Wright, and Jihan H. Talib

Protective interactions of dairy peptides with fibril structures and relevance to Alzheimer's disease, Louise Bennett, Williams Roderick, Heath Ecroyd, Yanqin Liu, Sunanda Sudharmarajan, and John A. Carver

PDF

Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials, Timothy P. Boyle, J. B. Bremner, Jonathan A. Coates, John Deadman, Paul A. Keller, Stephen G. Pyne, and Kittiya Somphol

A Facile Approach to 2-Substituted Isoflav-3-enes via Isoflavylium Salts, John B. Bremner, Jane Faragalla, Renate Griffith, and Andrew Heaton

Evidence for allelopathy as a mechanism of community composition change by an invasive exotic shrub, Chrysanthemoides monilifera spp. rotundata, John B. Bremner, Kristine O. French, and Emilie-Jane Ens

Identification of volatile compounds released by roots of an invasive plant, bitou bush (Chrysanthemoides monilifera spp. rotundata), and their inhibition of native seedling growth, John B. Bremner, Kristine O. French, Emilie-Jane Ens, and Jurgen Korth

Sodium translocation by the iminoglycinuria associated imino transporter (SLC6A20), Angelika Broer, Sarojini Balkrishna, Gabor Kottra, Sarah Davis, Aaron Oakley, and Stefan Broer

Novel Isoform-Specific Interfaces Revealed by PKA RII beta Holoenzyme Structures, Simon H. Brown, Jian Wu, Choel Kim, Kimberly Alberto, and Susan S. Taylor

PDF

The CD-loop of PAI-2 (SERPINB2) is redundant in the targeting, inhibition and clearance of cell surface uPA activity, Blake J. Cochran, Lakshitha P. Gunawardhana, Kara L. Perrow, Jodi A. Lee, Sergei A. Lobov, and Marie Ranson

PDF

Solid-state and solution-phase conformations of pseudoproline-containing dipeptides, James R. Cochrane, Nima Sayyadi, Danielle Skropeta, Peter Turner, Jack K. Clegg, and Katrina A. Jolliffe

PDF

Defining the structural basis of human plasminogen binding by streptococcal surface enolase, Amanda J. Cork; Slobodan Jergic; Sven Hammerschmidt; Bostjan Kobe; Vijay Pancholi; Justin L.P. Benesch; Carol V, Robinson; Nicholas E. Dixon; J Andrew Aquilina; and Mark J. Walker

PDF

Serotonin 2A receptor and its association with the pathology of schizophrenia, Chao Deng, Kai Kang, and Qing Wang

DNA Replication Prime-time looping, Nicholas E. Dixon

Phylogenetic approaches for the analysis of mitochondrial genome sequence data in the Hymenoptera - A lineage with both rapidly and slowly evolving mitochondrial genomes, Mark P. Dowton, Andrew D Austin, Stephen L. Cameron, and Michael F. Whiting

Characterization of 67 mitochondrial tRNA gene rearrangements in the hymenoptera suggests that mitochondrial tRNA gene position is selectively neutral, Mark P. Dowton, Andrew D Austin, Stephen L. Cameron, Michael F. Whiting, and Jessica Dowavic

PDF

Crystallin proteins and amyloid fibrils, Heath Ecroyd and John A. Carver

PDF

Apolipoprotein-E forms dimers in human frontal cortex and hippocampus, David A. Elliott, Glenda M. Halliday, and Brett Garner

Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities, Adel Garas, J. B. Bremner, Jonathon A. Coates, John Deadman, Paul A. Keller, Stephen G. Pyne, and David I. Rhodes

A new strategy for the stereoselective synthesis of 2,2'-bipyrrolidines, Mary Gresser, Paul A. Keller, and Steven Wales

PDF

(-)-Epigallocatechin-3-gallate (EGCG) maintains k-casein in its pre-fibrillar state without redirecting its aggregation pathway, Sean A. Hudson, Heath Ecroyd, Francis C. Dehle, Ian F. Musgrave, and John Carver

PDF

The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds, Sean A. Hudson, Heath Ecroyd, Tak W. Kee, and John A. Carver

The Gladstone (Australia) oil spill - Impacts on intertidal areas: Baseline and six months post-spill, Dianne F. Jolley, Felicity Melville, and L Andersen

PDF

Testicular descent, sperm maturation and capacitation. Lessons from our most distant relatives, the monotremes, Russell C. Jones, Heath Ecroyd, Jean-Louis Dacheux, and Brett Nixon

Metal-catalyzed cycloisomerization reactions of cis-4-hydroxy-5-alkynylpyrrolidinones and cis-5-hydroxy-6-alkynylpiperidinones: synthesis of Furo[3,2-b]pyrroles and Furo[3,2-b]pyridines, Jasmine C. Jury, Nalivela Swamy, Arife Yazici, Anthony C. Willis, and Stephen G. Pyne

Occurrence of phytoestrogens in municipal wastewater and surface waters, Jinguo Kang and William E. Price

Incorrect report of cryptic species within Chrysomya rufifacies (Diptera : Calliphoridae), Bryan D. Lessard, James F. Wallman, and Mark P. Dowton

Solvent dependence of electrochromic behaviour of polypyrrole: rediscovering the effect of molecular oxygen, Shannon Little, Stephen F. Ralph, Chee O. Too, and Gordon G. Wallace

Development and assessment of novel all-in-one parenteral formulations with integrated anticoagulant properties for the concomitant delivery of 5-fluorouracil and calcium folinate, Julie Locke, Tamantha Stutchbury, Kara Perrow, Allan Gamble, P Clingan, J. B. Bremner, and Marie Ranson

PDF

A novel zinc-binding fold in the helicase interaction domain of the Bacillus subtilis Dnal helicase loader, Karin V. Loscha, Kristaps Jaudzems, Charikleia Ioannou, Xun-Cheng Su, Flynn R. Hill, Gottfried Otting, Nicholas E. Dixon, and Edvards Liepinsh

The synthesis of carbon-linked bisbenzylisoquinolines via ruthenium-mediated olefin-metathesis, Uta Mbere-Nguyen, Alison Ung, and Stephen G. Pyne

DNA-based identification of forensically important Australian Sarcophagidae (Diptera), Kelly A. Meiklejohn, James F. Wallman, and Mark P. Dowton

PDF

Alkaloids from the Roots of Stemona aphylla, Pitchaya Mungkornasawakul, Sukanda Chaiyong, Thanapat Sastraruji, Araya Jatisatienr, Chaiwat Jatisatienr, Stephen G. Pyne, Alison T. Ung, Jurgen Korth, and Wilford Lie

PDF

Stemofoline ethyl acetate solvate, Pitchaya Mungkornasawakul, Stephen G. Pyne, Alison T. Ung, Araya Jatisatienr, and Anthony C. Willis

Polymorphic ROS scavenging revealed by CCCP in a lizard, Mats M. Olsson, Mark R. Wilson, Caroline Isaksson, and Tobias O. Uller

Ion exchange behaviour and charge compensation mechanism of polypyrrole in electrolytes containing mono-, di- and trivalent metal ions, William E. Price, Stephen F. Ralph, Marceline N. Akieh, Ari Ivaska, and Johan Bobacka

Examining the phylogeny of the Australasian Lymnaeidae (Heterobranchia: Pulmonata: Gastropoda) using mitochondrial, nuclear and morphological markers, Louise Puslednik, Winston Ponder, Mark Dowton, and Andrew R. Davis

Conformational rearrangements of plasminogen activator inhibitor type 2, Marie Ranson, Sergei A. Lobov, M Wilczynska, and T Ny

Cytotoxic and anticancer activities of Isatin and its derivatives: a comprehensive review from 2000-2008, Marie Ranson, Danielle Skropeta, Julie Locke, Lidia Matesic, and Kara L. Perrow

PDF

Structural revision of stemoburkilline from an E-Alkene to a Z-Alkene, Kwankamol Sastraruji, Stephen G. Pyne, Alison T. Ung, Pitchaya Mungkornawawakul, Wilford Lie, and Araya Jatisatienr

PDF

Synthesis and applications of covalent protein-DNA conjugates, Patrick M. Schaeffer and Nicholas E. Dixon

An adsorption study of alum-morin dyeing onto silk yarn, Chutima Septhum, Saowanee Rattanaphani, John B. Bremner, and Vichitr Rattanaphani

The effect of individual N-glycans on enzyme activity, Danielle Skropeta

PDF

From powder to solution: hydration dependence of human hemoglobin dynamics correlated to body temperature, A. M. Stadler, I. Digel, J. P. Embs, T. Unruh, Moeava Tehei, G. Zaccai, G. Büldt, and G. M. Artmann

PDF

Development and application of a system for the analysis of atmospheric, water and sediment nitrogen and carbon, Ann Stavert, Stephen R. Wilson, and Dianne F. Jolley

PDF

Model for amorphous aggregation processes, Samual Stranks, Heath Ecroyd, Steve Van Sluyter, Elizabeth J. Waters, John A. Carver, and Lorenz von Smekal

A mass spectrometric investigation of the ability of metal complexes to modulate transcription factor activity, Jihan H. Talib, Jennifer L. Beck, Thitima Urathamakul, Cong Duc Nguyen, Janice Aldrich-Wright, Joel P. Mackay, and Stephen Frederick Ralph

PDF

Real-time single-molecule observation of rolling-circle DNA replication, Nathan A. Tanner, Joseph J. Loparo, Samir M. Hamdan, Slobodan Jergic, Nicholas E. Dixon, and Antoine M. van Oijen

Mapping protein dynamics conformational changes in replisomal macromolecular assemblies, Moeava Tehei, Flynn Hill, Charikleia Ioannou, M M Koza, Lambert van Eijck, and Nicholas E. Dixon

PDF

Online ozonolysis methods for the determination of double bond position in unsaturated lipids, Michael Thomas, Todd W. Mitchell, and Stephen J. Blanksby

Link

The two faced nature of milk casein proteins: amyloid fibril formation and chaperone-like activity, David Thorn, Heath Ecroyd, and John A. Carver

PDF

Identification of abundant alkyl ether glycerophospholipids in the human lens by tandem mass spectrometry techniques, Roger J. Truscott, Jane Deeley, Todd W. Mitchell, Michael Thomas, and Stephen J. Blanksby

PDF

Thermal attributes of Chrysomya species, James F. Wallman, Leigh Nelson, and Mark P. Dowton

Tolerance induction by removal of alloreactive T cells: in-vivo and pruning strategies, Debbie Watson, Min Hu, Geoff Y. Zhang, Yuan M. Wang, and Stephen I. Alexander

CCL2 DNA vaccine to treat renal disease, Debbie Watson, Guoping Zheng, Huiling Wu, Yuan Min Wang, Yiping Wang, David C. H Harris, and S I. Alexander

Variation in levels of reactive oxygen species is explained by maternal identity, sex and body-size-corrected clutch size in a lizard, Mark R. Wilson, Mats M. Olsson, Tobias O. Uller, Caroline Isaksson, and Beth Mott

PDF

Therapeutic targets in extracellular protein deposition diseases, Amy R. Wyatt, Justin J. Yerbury, Stephen Poon, and Mark R. Wilson

PDF

Structural characterization of clusterin-chaperone client protein complexes, Amy R. Wyatt, Justin J. Yerbury, and Mark R. Wilson

The chaperone action of clusterin and its putative role in quality control of extracellular protein folding, Amy Wyatt, Justin J. Yerbury, Stephen Poon, Rebecca Dabbs, and Mark Wilson

Cell-free synthesis and combinatorial selective 15 N-labeling of the cytotoxic protein amoebapore A from Entamoeba histolytica, Yang Xun, Pierre Tremouilhac, Colm Carraher, Christoph Gelhaus, Kiyoshi Ozawa, Gottfried Otting, Nicholas E. Dixon, Matthias Leippe, Joachim Grotzinger, Andrew Dingley, and Andrew Kralicek

Optimized production and analysis of the staphylococcal multidrug efflux protein QacA, Zhi-Qiang Xu, RE Watkins, RG Brennan, KA Hassan, RA Skurray, and MH Brown

PDF

Intermolecular addition reactions of N-acyliminium ions (Part I), Arife Yazici and Stephen G. Pyne

PDF

Intermolecular addition reactions of N-acyliminium ions (Part II), Arife Yazici and Stephen G. Pyne

Reactions of electron-rich indoles with triflic anhydride, Nageshwar Rao Yepuri, Rachada Haritakul, Paul A. Keller, Brian Skelton, and Allan White

PDF

Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species, Justin J. Yerbury, Janet R. Kumita, Sarah Meehan, Christopher M. Dobson, and Mark R. Wilson

Hydration number, topological control, and ion selectivity, Haibo Yu, Sergei Noskov, and Benoit Roux

PDF

On the utilization of energy minimization to the study of ion selectivity, Haibo Yu and Benoit Roux

Papers from 2008

Link

Cell-free protein synthesis for analysis by NMR spectroscopy, Margit A. Apponyi, Kiyoshi Ozawa, Nicholas E. Dixon, and Gottfried Otting

A comparison of the binding of metal complexes to duplex and quadruplex DNA, Jennifer L. Beck, Stephen F. Ralph, Janice Aldrich-Wright, Thitima Urathamakul, Charlotte Green, Kimberley Davis, and Jihan H. Talib

Phospholipid composition of the rat lens is independent of diet, Stephen J. Blanksby, Roger J. Truscott, Todd W. Mitchell, Anthony J. Hulbert, Sarah K. Abbott, and Jessica Hughes

S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1, Philip G. Board, Marjorie Coggan, Jean Cappello, Huina Zhou, Aaron J. Oakley, and Marion W. Anders

PDF

New Cyclic Peptides via Ring-Closing Metathesis Reactions and Their Anti-Bacterial Activities, Timothy P. Boyle, John B. Bremner, Jonathan Coates, John Deadman, Paul A. Keller, Stephen G. Pyne, and David I. Rhodes

Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus, John B. Bremner, Michael J. Kelso, Joseph Ambrus, Kim Lewis, Anthony R. Ball, and Gabriele Casadei

N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents, John B. Bremner, Stephen G. Pyne, Marie Ranson, Danielle Skropeta, Julie Locke, Lidia Matesic, and Kara L. Perrow

Adsorption kinetic study of lac dyeing on cotton, John B. Bremner, Saowanee Rattanaphani, Montra Chairat, and Vichitr Rattanaphani

1,2-Oxazepines and 1,2-Thiazepines, John B. Bremner and Siritron Samosorn

1,3-Oxazepines and 1,3-Thiazepines, John B. Bremner and Siritron Samosorn

Azepines and their Fused-ring Derivatives, John B. Bremner and Siritron Samosorn

Seven-membered rings, John B. Bremner and Siritron Samosorn

A compact approach to an Isomeric Iheyamine a system and x-ray crystal structure of 5-Methyl-5H-azepino[2,3-b:4,5-b']diindole, John B. Bremner, Waya Sengpracha, and Brian W. Skelton

Subtle structural variation in copper metal-organic frameworks: syntheses, structures, magnetic properties and catalytic behaviour, Andrew Burrows, Christopher Frost, Mary Mahon, Melanie Winsper, Christopher Richardson, J. Attfield, and Jennifer Rodgers

Characterization of gibberellin receptor mutants of barley (Hordeum vulgare L.), Peter M. Chandler, Carol A. Harding, Anthony R. Ashton, Mark D. Mulcair, Nicholas E. Dixon, and Lewis N. Mander

PDF

Synthetic and spectroscopic studies on the structures of uniflorines A and B: structural revision to 1,2,6,7-tetrahydroxy-3-hydroxymethylpyrrolizidine alkaloids, Andrew S. Davis, Thunwadee Ritthiwigrom, and Stephen G. Pyne

Microprobe XRF mapping and XAS investigations of the intracellular metabolism of arsenic for understanding arsenic-induced toxicity, Carolyn T. Dillon, H.H. Harris, B. Lai, Z. Cai, Amalanie J. Foster, Andrejs Klavins, Stefan Vogt, Anna Mariana, and Kristie Gill