Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials

Authors

Timothy P. Boyle, University of Wollongong
J. B. Bremner, University of WollongongFollow
Jonathan A. Coates, Avexa Ltd
John Deadman, Avexa Ltd
Paul A. Keller, University of WollongongFollow
Stephen G. Pyne, University of WollongongFollow
Kittiya Somphol, University of Wollongong

RIS ID

30147

Publication Details

Boyle, T. P., Bremner, J. B., Coates, J. A., Deadman, J., Keller, P. A., Pyne, S. G. & Somphol, K. (2009). Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials. European Journal of Medicinal Chemistry, 44 (3), 1001-1009.

Abstract

An efficient synthesis of two new N-acetyl-4’-arylphenylalanines is described together with their incorporation in to a number of cationic peptoid antibacterial agents, one of which had an MIC of 7.8 μg/mL against Staphylococcus aureus.