Molecular Horizons - formerly the Centre for Medical and Molecular Bioscience (CMMB) - brings together a multidisciplinary team of chemists and biologists with a common interest in the molecular basis of disease and disease prevention from the School of Chemistry and School of Biological Sciences at the University of Wollongong.

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Papers from 2006

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Dichlorobis(2,5-diphenyl-1,3,4-thia­diazole-κN3)palladium(II), Peter Steel and Christopher Richardson

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Development of robust guidelines and assessment procedures for metal contaminated sediments, David Strom, Stuart L. Simpson, and Dianne F. Jolley

Site-specific labelling of proteins with a rigid lanthanide-binding tag, Xun Cheng Su, Thomas Huber, Nicholas E. Dixon, and Gottfried Otting

Monomeric solution structure of the helicase binding domain of Escherichia coli DnaG primase, Xun-Cheng Su, Patrick M. Schaeffer, Karin V. Loscha, Pamela H.P Gan, Nicholas E. Dixon, and Gottfried Otting

3-Hydroxykynurenine oxidizes alpha-crystallin: potential role in cataractogenesis, Roger J. Truscott, Andrew Aquilina, Peter Hains, and Anastasia Korlimbinis

Inhibition of indoleamine 2,3 dioxygenase activity by H2O2, Roger J. Truscott, Mark J. Walker, Joanne Jamie, Tamantha Littlejohn, Osamu Takikawa, Chris J.D Austin, Perminder Sachdev, George A. Smythe, Anne Poljak, Ross Grant, and Robert D. Willows

Divergence in the plasminogen-binding group A streptococcal M protein family, Mark J. Walker, Mark P. Dowton, Marie Ranson, Martina L. Sanderson-Smith, Kadaba S Sriprakash, and Michael Batzloff

Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin., Yuan Min Wang, Geoff Zhang, Yiping Wang, Min Hu, Huiling Wu, Debbie Watson, Shohoi Hori, Ian Alexander, David Harris, and Stephen I. Alexander

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Comparison of virulence gene profiles between Escherichia coli strains isolated from healthy and diarrheic swine, Mark R. Wilson, Xi Yang Wu, Idris Barchia, Karl A Bettelheim, Steven Driesen, Darren J. Trott, Toni A. Chapman, and James J C Chin

Amino-acid type identification in 15N-HSQC spectra by combinatorial selective 15N-labelling, Peter S.C Wu, Kiyoshi Ozawa, Slobodan Jergic, Xun Cheng Su, Nicholas E. Dixon, and Gottfried Otting

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The Synthesis and Testing of Arenearylpyrimidylmethanes (AAPM) as Anti-Malarial Agents, N. R. Yepuri, R. Haritakul, R. Griffith, S. P. Leach, and Paul A. Keller

Molecular dynamics simulations of liquid methanol and methanol-water mixtures with polarizable models, Haibo Yu, Daan Geerke, Haiyan Liu, and Wilfred van Gunsteren

Molecular dynamics study of the stabilities of consensus designed ankyrin repeat proteins, Haibo Yu, Andreas Kohl, H. Kaspar Binz, Andreas Plueckthun, Markus Gruetter, and Wilfred van Gunsteren

DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injury, Guoping Zheng, Yiping Wang, Shi-Hua Xiang, Yuet-Ching Tay, Huiling Wu, Debbie Watson, Jason Coombes, Gopala K. Rangan, Stephen I. Alexander, and David C. H Harris

Papers from 2005

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Structural re-assignment of the mono- and bis-addition products from the addition reactions of N-(diphenylmethylene)glycinate esters to [60]fullerene under Bingel conditions, Graham E Ball, Glenn Ashley Burley, Leila Chaker, William Hawkins, James Williams, Paul A. Keller, and Stephen G. Pyne

Identification of bifunctional GA and AG intrastrand crosslinks formed between cisplatin and DNA, Jennifer L. Beck, Stephen F. Ralph, Rajesh Gupta, and Margaret Sheil

Three-dimensional structure of (1,4)-β-D-mannan mannanohydrolase from tomato fruit, Richard Bourgault, Aaron Oakley, J Bewley, and Matthew Wilce

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A convenient and efficient synthesis of (S)-lysine and (S)-arginine homologues via olefin cross-metathesis, Timothy P. Boyle, John B. Bremner, Jonathan A. Coates, Paul A. Keller, and Stephen G. Pyne

Seven-membered ring systems, John B. Bremner

Free fatty acids and sterols in the benthic spawn of aquatic molluscs and their associated antimicrobial properties, John B. Bremner, Andrew R. Davis, Kirsten Benkendorff, and Cary Rogers

Synthesis of functionalised azecine and azonine derivatives via an enolate assisted aza Claisen rearrangement, John B. Bremner and David F. Perkins

An adsorption and kinetic study of lac dyeing on silk, John B. Bremner, Saowanee Rattanaphani, Montra Chairat, and Vichitr Rattanaphani

A free radical cyclization approach to indolo-benzodiazocine derivatives, John B. Bremner and Waya Sengpracha

An iodoacetamide-based free radical cyclisation approach to the 7,12-dihydro-indolo[3,2-d][1]benzazepin-6(5H)-one (paullone) system, John B. Bremner and Waya Sengpracha

Atroposelective synthesis of axially chiral biaryl compounds, Gerhard Bringmann, Anne J. Price Mortimer, Paul A. Keller, Mary J. Gresser, James Garner, and Matthias Breuning

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Regioselective synthesis of novel e-edge-[60]fullerenylmethanodihydropyrroles and 1,2-dihydromethano[60]fullerenes, Leila Chaker, Graham E. Ball, James R. Williams, Glenn A. Burley, Bill C. Hawkins, Paul A. Keller, and Stephen G. Pyne

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Tandem mass spectrometry of deprotonated iodothyronines, A. M. Couldwell, M. C. Thomas, Todd Mitchell, A. Hulbert, and Stephen J. Blanksby

Intracellular Mapping of the Distribution of Metals Derived from the Antitumor Metallocenes, Carolyn T. Dillon, Margaret M. Harding, H.H. Harris, B. Lai, J.B. Waern, and Z. Cai

Systematics, evolution, and biology of scelionid and platygastrid wasps, Mark P. Dowton, Andrew D Austin, and Neil F. Johnson

The position of the Hymenoptera within the Holometabola as inferred from the mitochondrial genome of Perga condei (Hymenoptera: Symphyta: Pergidae), Mark P. Dowton and Lyda Castro

A complex mechanism controls polarity of DNA replication fork arrest by the replication terminator complex of Bacillus subtilis, Iain G. Duggin, Jacqueline M. Matthews, Nicholas E. Dixon, R Gerry Wake, and Joel P. Mackay

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The epididymal soluble prion protein forms a high-molecular-mass complex in association with hydrophobic proteins, Heath W. Ecroyd, Maya Belghazi, Jean-Louis Dacheux, and Jean-Luc Gatti

Solid-state conformations of symmetrical aromatic biheterocycles: an X-ray crystallographic investigation, Christopher Fitchett, Christopher Richardson, and Peter Steel

Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia, Samantha Ginn, Julie A. Curtin, Belinda Kramer, Christine M. Smyth, Melanie Wong, Alyson Kakakios, Geoffrey B. McCowage, Debbie Watson, Stephen I. Alexander, Margot Latham, Sharon C. Cunningham, Maolin Zheng, Linda Hobson, Peter B. Rowe, Alain Fischer, Marina Cavazzana-Calvo, Salima Hacein-Bey-Abina, and Ian E. Alexander

Weak alignment of paramagnetic proteins warrants correction for residual CSA effects in measurements of pseudocontact shifts, Michael John, Ah-Young Park, Guido Pintacuda, Nicholas E. Dixon, and Gottfried Otting

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Factors affecting metal releases from contaminated marine sediments, Dianne F. Jolley, Clare A. Atkinson, and Stuart L. Simpson

Product Class 11: Phenanthridines, Paul A. Keller

Product Class 12: Phenanthridinones and Related Systems, Paul A. Keller

Product Class 2: Pyridinones and Related Systems, Paul A. Keller

A convenient and efficient synthesis of (S)-lysine and (S)-arginine homologues via olefin cross-metathesis, Paul A. Keller, John B. Bremner, Stephen G. Pyne, Jonathon A Coates, and Timothy Boyle

Control of Hepatitis C: A Medicinal Chemistry Perspective, Paul A. Keller and Christopher Gordon

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Enzyme activity and flexibility at very low hydration, V Kurkal, R M. Daniel, John L. Finney, Moeava Tehei, R V. Dunn, and Jeremy C. Smith

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Toxicity, biotransformation, and mode of action of arsenic in two freshwater microalgae (Chlorella sp. and Monoraphidium arcuatum), Jacqueline L. Levy, Jennifer L. Stauber, Merrin S. Adams, William A. Maher, Jason K. Kirby, and Dianne F. Jolley

An experimental study of effects of adenovirus-mediated cardiotrophin-1 gene transfer into neural stem cells, Hongyun Li

Nogo and axonal regeneration, Hongyun Li

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Confirmation of the structure of oxystemokerrin by single crystal x-ray structural analysis and a proposed biosynthesis, Pitchaya Mungkornasawakul, Hayden Matthews, Alison T. Ung, Stephen G. Pyne, Araya Jatisatienr, Wilford Lie, Brian W. Skelton, and Allan H. White

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Replication termination in Escherichia coli: Structure and anti-helicase activity of the Tus-Ter complex, Cameron Neylon, Andrew V. Kralicek, Thomas M. Hill, and Nicholas E. Dixon

Glutathione transferases: new functions, Aaron J. Oakley

Crystal and solution structures of the helicase-binding domain of Escherichia coli primase, Aaron J. Oakley, Karin V. Loscha, Patrick M. Schaeffer, Edvards Liepinsh, Guido Pintacuda, Matthew C.J Wilce, Gottfried Otting, and Nicholas E. Dixon

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Fractionation of sedimentary arsenic from Port Kembla Harbour, NSW, Australia, Glennys A. O'Brien, William E. Price, Bryan E. Chenhall, and muhammad damris

Cell-free synthesis of 15N-labeled proteins for NMR studies, Kiyoshi Ozawa, Nicholas E. Dixon, and Gottfried Otting

Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins, Kiyoshi Ozawa, Madeline J. Headlam, Dmitri Mouradov, Stephen J. Watt, Jennifer L. Beck, Kenneth J. Rodgers, Roger T. Dean, Thomas Huber, Gottfried Otting, and Nicholas E. Dixon

Cell-free protein synthesis in an autoinduction system for NMR studies of protein-protein interactions, Kiyoshi Ozawa, Slobodan Jergic, Jeffrey A. Crowther, Philip R. Thompson, Gene Wijffels, Gottfried Otting, and Nicholas E. Dixon

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Synthesis of carbocyclic hydantocidins via regioselective and diastereoselective phosphine-catalyzed [3+2]-cycloadditions to 5-methylenehydantoins, Tien Quoc Pham, Stephen G. Pyne, Brian W. Skelton, and Allan H. White

Recent developments on the synthesis of (-)-swainsonine and analogues, Stephen G. Pyne

Metal transport studies on inherently conducting polymer membranes containing cyclodextrin dopants, Stephen F. Ralph, Gordon G. Wallace, and David Reece

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Autopolymerization of pyrrole in the presence of a host/guest calixarene, David A. Reece, Jennifer M. Pringle, Stephen F. Ralph, and Gordon G. Wallace

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Phytochemical studies on Stemona plants: isolation of stemofoline alkaloids, Thanapat Sastraruji, Araya Jatisatienr, Stephen G. Pyne, Alison T. Ung, Wilford Lie, and Morwenna C. Williams

Protein-protein interactions in the eubacterial replisome, Patrick M. Schaeffer, Madeleine J. Headlam, and Nicholas E. Dixon

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Purification, crystallization and preliminary crystallographic analysis of DehIVa, a dehalogenase from Burkholderia cepacia MBA4, Jason Schmidberger, Aaron Oakley, Jimmy Tsang, and Matthew Wilce

The structure, biological activities and synthesis of 3-hydroxylpyrrolizidine alkaloids and related compounds, Minyan Tang and Stephen G. Pyne

Neutron scattering reveals the dynamic basis of protein adaptation to extreme temperature, Moeava Tehei, Dominique Madern, Bruno Franzetti, and Giuseppe Zaccai

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A comparison of the gas phase acidities of phospholipid headgroups:experimental and computational studies, M. C. Thomas, Todd Mitchell, and Stephen J. Blanksby

Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase, Roger J. Truscott, S. Bertin, F. Cog, P. Delagrange, G. Ferry, C. Ubeaud, P. Chomarat, and P.H. Lambert

Synthesis and antagonist activities of 4-aryl-substituted conformationally restricted cyclopentenyl and cyclopentanyl-glutamate analogues, Alison T. Ung, Stephen G. Pyne, Uta Batenburg-Nguyen, Andrew S. Davis, Azlifa Shareef, Francois Bischoff, and Anne S. J Lesage

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Is plasminogen deployed as a Streptococcus pyogenes virulence factor?, Mark J. Walker, Jason D. McArthur, F. McKay, and M. Ranson

Research progress of repairing the injured spinal cord on the target of NgR, W T. Wang, X M. Lu, and Hongyun Li

Comparison of negative and positive ion electrospray ionization mass spectra of calmodulin and its complex with trifluoperazine, Stephen James Watt, Aaron J. Oakley, Margaret Sheil, and Jennifer L. Beck

Conservation of eubacterial replicases, Gene Wijffels, Brian Dalrymple, Kritaya Kongsuwan, and Nicholas E. Dixon

Stabilization of native protein fold by intein-mediated covalent cyclization, Neal K. Williams, Edvards Liepinsh, Stephen J. Watt, Pavel Prosselkov, Jacqueline M. Matthews, Phil Attard, Jennifer L. Beck, Nicholas E. Dixon, and Gottfried Otting

Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species, Mark R. Wilson, M. M. Dedmon, J. Christodoulou, and Christopher Dobson

Lymphotoxin-beta receptor-dependent genes in lymph node and follicular dendritic cell transcriptomes, Mark R. Wilson, C. Huber, C. Thielen, Y. Fu, E. Heinen, A Aguzzi, and G Miele

Amyloid fibril formation by bovine milk kappa-casein and its inhibition by the molecular chaperones alpha-s and beta-casein, Mark R. Wilson, David Thorn, Agata Rekas, S. L Gras, Christopher Dobson, Sarah Meehan, Cait MacPhee, and M Sunde

Adenovirus-mediated cardiotrophin-1 gene for modifying neural stem cells in rats, Y Yang, W-H Liao, Z Zhang, D Li, and Hongyun Li

The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin, Justin J. Yerbury, Mark S Rybchyn, Simon B Easterbrook-Smith, C. Henriques, and Mark R. Wilson

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Synthesis of 2-azaspiro[4.4]nonan-1-ones via phosphine-catalysed [3+2]-cycloadditions, Sarah Yong, Morwenna C. Williams, Stephen G. Pyne, Alison T. Ung, Brian W. Skelton, Allan H. White, and P. Turner

Accounting for polarization in molecular simulation, Haibo Yu and Wilfred van Gunsteren

Papers from 2004

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Analysis of the mechanism by which calcium negatively regulates the tyrosine phosphorylation cascade associated with sperm capacitation, Mark Baker, Louise Hethrington, Heath W. Ecroyd, Shaun D. Roman, and Robert J. Aitken

Direct observation of covalent adducts with Cys34 of human serum albumin using mass spectrometry, Jennifer L. Beck, Shanika Ambahera, Sarah R. Yong, Margaret Sheil, J de Jersey, and Stephen F. Ralph

Electroless recovery of gold chloride using inherently conducting polymers, Jie Ding, William E. Price, Stephen F. Ralph, and Gordon G. Wallace

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The development of signal transduction pathways during epididymal maturation is calcium dependent, Heath W. Ecroyd, Kelly Asquith, Russell C. Jones, and Robert J. Aitken

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Compartmentalization of prion isoforms within the reproductive tract of the ram, Heath W. Ecroyd, Pierre Sarradin, Jean-Louis Dacheux, and Jean-Luc Gatti

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On the transferability of the SPCAL water model to biomolecular simulation, Alice Glaettli, Chris Oostenbrink, Xavier Daura, Daan Geerke, Haibo Yu, and Wilfred van Gunsteren

Application of electrospray ionization mass spectrometry to study the hydrophobic interaction between the ε and θ subunits of DNA polymerase III, Rajesh Gupta, Samir M. Hamdan, Nicholas E. Dixon, Margaret M. Sheil, and Jennifer L. Beck

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Protecting group effects on the efficiency of the ruthenium-catalyzed Alder-ene reaction, Joseph Hartley and Stephen G. Pyne

Matching T-cell receptors identified in renal biopsies and urine at the time of acute rejection in pediatric renal transplant patients, Min Hu, Geoff Y. Zhang, Giles Walters, Mary Sartor, Debbie Watson, John F. Knight, and Stephen I. Alexander

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Selenium accumulation in the cockle Anadara trapezia, Dianne F. Jolley, William A. Maher, and Jennelle Kyd

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Studies on the synthesis of croomine: synthesis of the tricyclic B,C,D-ring core structure, Karl B. Lindsay and Stephen G. Pyne

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Synthesis of (+)-(1R,2S,9S,9aR)-octahydro-1H-pyrrolo-[1,2-a]azepine-1,2,9-triol: a potential glycosidase inhibitor, Karl B. Lindsay and Stephen G. Pyne

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Asymmetric synthesis of (-)-swainsonine, Karl Lindsay and Stephen G. Pyne

Expression, purification, crystallization, and NMR studies of the helicase interaction domain of Escherichia coli DnaG primase, Karin Loscha, Aaron J. Oakley, Bogdan Bancia, Patrick M. Schaeffer, Pavel Prosselkov, Gottfried Otting, Matthew C.J Wilce, and Nicholas E. Dixon

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Intranasal Vaccination with Streptococcal Fibronectin Binding Protein Sfb1 Fails To Prevent Growth and Dissemination of Streptococcus pyogenes in a Murine Skin Infection Model, Jason D. McArthur, E. Medina, J. Chin, B. J. Currie, K. S. Sriprakash, S. R. Talay, G. S. Chhatwal, and Mark J. Walker

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Immune responses of a liposome/ISCOM vaccine adjuvant against streptococcal fibronectin binding protein 1 (Sfb1) in mice, Jason D. McArthur, K Schulze, James Chin, B J. Currie, K S. Sriprakash, S R. Talay, G S. Chhatwal, C A. Guzman, and Mark J. Walker

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Plasminogen binding by group A streptococcal isolates from a tropical region with hyperendemic streptococcal skin infection and a high incidence of invasive infection, F. C. McKay, Jason D. McArthur, Martina L. Sanderson-Smith, S. Gardam, B. J. Currie, K. S. Sriprakash, P. K. Fagan, R. J. Towers, M. R. Batzloff, G. S. Chhatwal, Marie Ranson, and Mark J. Walker

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Phytochemical studies on Stemona burkillii Prain: Two new dihydrostemofoline alkaloids, Pitchaya Mungkornasawakul, Stephen G. Pyne, Araya Jatisatienr, Wilford Lie, Alison T. Ung, Kritchaya Issakul, Auntika Sawatwanich, Damrat Supyen, and Chaiwat Jatisatienr

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Phytochemical and larvicidal studies on Stemona curtisii: Structure of a new pyriodo[1,2-a]azepine Stemona alkaloid, Pitchaya Mungkornasawakul, Stephen G. Pyne, Araya Jatisatienr, Damrat Supyen, Chaiwat Jatisatienr, Wilford Lie, Alison T. Ung, Brian W. Skelton, and Allan H. White

Optimization of an Escherichia coli system for cell-free synthesis of selectively 15N-labelled proteins for rapid analysis by NMR spectroscopy, Kiyoshi Ozawa, Madeleine J. Headlam, Patrick M. Schaeffer, Blair R. Henderson, Nicholas E. Dixon, and Gottfried Otting

Fast structure-based assignment of 15N HSQC spectra of selectively 15N-labeled paramagnetic proteins, Guido Pintacuda, Max A Keniry, Thomas Huber, Ah-Young Park, Nicholas E. Dixon, and Gottfried Otting

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Asymmetric synthesis of polyfunctionalized pyrrolidines and related alkaloids, Stephen G. Pyne, Andrew S. Davis, Nicole Gates, Joseph Hartley, Karl Lindsay, Theeraphan Machan, and Minyan Tang

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Two distinct genotypes of prtF2, encoding a fibronectin binding protein, and the evolution of the gene family in Streptococcus pyogenes, V. Ramachandran, Jason D. McArthur, C. E. Behm, C. Gutzeit, M. Dowton, P. K. Fagan, R. Towers, B. J. Currie, K. S. Sriprakash, and Mark J. Walker