The Illawarra Health and Medical Research Institute is a partnership between the University of Wollongong and the South Eastern Sydney Illawarra Area Health Service. IHMRI's research focuses on health and medical issues that are common in the Illawarra region and is aimed at improving the health and well being of the local community. IHMRI's goal is to foster research collaboration through the IHMRI Research Network, creating a centre of excellence and innovation that represents the focal point of health and medical research in this region.

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Papers from 2015

Fatty acid composition of the anterior cingulate cortex indicates a high susceptibility to lipid peroxidation in Parkinson's disease, Sarah K. Abbott, Andrew M. Jenner, Adena S. Spiro, Marijka Batterham, Glenda M. Halliday, and Brett Garner

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NMDA receptor antagonism by phencyclidine reduces NWASP and WAVE1 protein expression and reduces levels of myelination markers in the prefrontal cortex of rats, Jessica L. Andrews, Kelly A. Newell, Natalie Matosin, Xu-Feng Huang, and Francesca Fernandez-Enright

Altered IL-2, IL-6 and IL-8 serum levels in schizophrenia patients with tardive dyskinesia, Hui-Mei An, Yun Long Tan, Jing Shi, Zhi-Ren Wang, Jair C. Soars, Jing Qin Wu, Fu-De Yang, Xu-Feng Huang, and Xiang Yang Zhang

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Is B-type natriuretic peptide a risk factor for heart failure in patients treated with bardoxolone methyl?, Danielle Camer and Xu-Feng Huang

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Palmitic acid induces central leptin resistance and impairs hepatic glucose and lipid metabolism in male mice, Licai Cheng, Yinghua Yu, Alexander M. Szabo, Yizhen Wu, Hongqin Wang, Danielle Camer, and Xu-Feng Huang

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Differential effects of short- and long-term antipsychotic treatment on the expression of neuregulin-1 and ErbB4 receptors in the rat brain, Chao Deng, Bo Pan, Chang-Hua Hu, Mei Han, and Xu-Feng Huang

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Neuregulin 1 prevents phencyclidine-induced behavioral impairments and disruptions to GABAergic signaling in mice, Martin Engel, Peta Snikeris, Andrew M. Jenner, Tim Karl, Xu-Feng Huang, and Elisabeth T. Frank

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Comparing alternative design options for chronic disease prevention interventions, Mohammad Golfam, Reed Beall, Jamie Brehaut, Sara Saeed, Clare Relton, Fred D. Ashbury, and Julian Little

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Cognitive differences in schizophrenia on long-term treatments with clozapine, risperidone and typical antipsychotics, Mei Han, Xiang Yang Zhang, Da Chun Chen, Yun Long Tan, Chong Sheng Song, Yinghua Yu, and Xu-Feng Huang

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Nutrient essentiality revisited, Stephanie Jew, Jean-Michel Antoine, Pierre Bourlioux, John Milner, Linda C. Tapsell, Yuexin Yang, and Peter J. H Jones

Predicting support and likelihood of protest in relation to the use of treated stormwater with managed aquifer recharge for potable and non-potable purposes, Rosemary Leonard, Aditi Mankad, and Kim Alexander

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Chronic betahistine co-treatment reverses olanzapine's effects on dopamine D2 but not 5-HT2A/2C bindings in rat brains, Jiamei LIAN, Xu-Feng Huang, Nagesh B. Pai, and Chao Deng

Farmers' perceptions of and responses to annual flood events in the Vietnamese Mekong River Delta: adapting to climate change impacts, Van Kien Nguyen and Kim Alexander

Improved pharmacokinetic and biodistribution properties of the selective urokinase inhibitor PAI-2 (SerpinB2) by site-specific PEGylation: implications for drug delivery, Kara L. Vine, Sergei Lobov, Vineesh Indira Chandran, Nathanial Harris, and Marie Ranson

Papers from 2014

Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson's disease, Sarah Abbott, Hongyun Li, Sonia Sanz Munoz, Bianca Knoch, Marijka Batterham, Karen E. Murphy, Glenda M. Halliday, and Brett Garner

A vision for chronic disease prevention and intervention research: report from a workshop, Fred D. Ashbury, Julian Little, John P.A Ioannidis, Nancy Kreiger, Lyle J. Palmer, Clare Relton, and Peter Taylor

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Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism, Archana Bhaskaracharya, Phuong Dao-Ung, Iman Jalilian, Mari Spildrejorde, Kristen K. Skarratt, Stephen Fuller, Ronald Sluyter, and Leanne Stokes

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Cancer biology: molecular and genetic basis, Ulrich A. Bommer, Kara L. Vine, and Oncology Education Committee Cancer Council Australia

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Trust, continuity and agency: keys to understanding older patients' attitudes to general practice trainees, Andrew Bonney, Sandra C. Jones, Donald C. Iverson, and Christopher Magee

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Comment on: Oleanolic acid co-administration alleviates ethanol-induced hepatic injury via Nrf-2 and ethanol-metabolizing modulation (sic) in rats, Danielle Camer and Xu-Feng Huang

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The endothelin pathway: a protective or detrimental target of bardoxolone methyl on cardiac function in patients with advanced chronic kidney disease?, Danielle Camer and Xu-Feng Huang

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The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications, Danielle Camer, Yinghua Yu, Alexander Szabo, and Xu-Feng Huang

Increased expression of astrocyte markers in schizophrenia: association with neuroinflammation, Vibeke Sørensen Catts, Jenny Wong, Stu Gregory Fillman, Samantha J. Fung, and Cynthia S. Weickert

Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1ΔE9 mice, David Cheng, Jac Kee Low, Warren Logge, Brett Garner, and Tim Karl

Novel behavioural characteristics of female APPswe/PS1ΔE9 double transgenic mice, David Cheng, Jac Kee Low, Warren Logge, Brett Garner, and Tim Karl

The role of Src in colon cancer and its therapeutic implications, Jiezhong Chen, Aymen Elfiky, Mei Han, Chen Chen, and M Wasif Saif

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Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH) loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways, Jiezhong Chen, Renfu Shao, Li Li, Zhi Ping Xu, and Wenyi Gu

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Insulin induces drug resistance in melanoma through activation of the PI3K/Akt pathway, Mengna Chi, Yan Ye, Xu Dong Zhang, and Jiezhong Chen

Site-restricted plasminogen activation mediated by group A streptococcal streptokinase variants, Simon M. Cook, Amanda Skora, Mark J. Walker, Martina L. Sanderson-Smith, and Jason D. McArthur

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Emotion perception and electrophysiological correlates in Huntington's disease, Rodney J. Croft, F Mckernan, M Gray, A Churchyard, and Nellie Georgiou-Karistianis

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Finding measures of clinical placements quality for pre-service health services training: challenges of definition and search strategy construction, Anne Cusick, Marie Heydon, Katherine Caldwell, and Linda Cohen

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Validating the Western Neuro Sensory Stimulation Profile for patients with severe traumatic brain injury who are slow-to-recover, Anne Cusick, Natasha Lannin, Robyn Hanssen, and Jeanine Allaous

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Expression and purification of chaperone-active recombinant clusterin, Rebecca Dabbs and Mark R. Wilson

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Different effects of Bifeprunox, Aripiprazole, and Haloperidol on body weight gain, food and water intake, and locomotor activity in rats, Michael De Santis, Bo Pan, Jiamei Lian, Xu-Feng Huang, and Chao Deng

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Implementing a regional oncology information system: approach and lessons learned, W K. Evans, Fred D. Ashbury, G L. Hogue, A Smith, and J Pun

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Novel implications of Lingo-1 and its signaling partners in schizophrenia, F Fernandez-Enright, J L. Andrews, K A. Newell, C Pantelis, and Xu-Feng Huang

Detection, quantification, and total synthesis of novel 3-hydroxykynurenine glucoside-derived metabolites present in human lenses, Nicholas A. Gad, Jasminka Mizdrak, David I. Pattison, Michael J. Davies, Roger J. W Truscott, and Joanne F. Jamie

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GluN2B protein deficits in the left, but not the right, hippocampus in schizophrenia, Amy Geddes, Xu-Feng Huang, and Kelly Newell

Menses, fertility and pregnancy following the use of balloon tamponade technology in the management of postpartum haemorrhage, Christos Georgiou

Semantic monitoring and compensation in socio-technical processes, Yingzhi Gou, Aditya Ghose, Chee Fon Chang, Hoa Dam, and Andrew Alexis Miller

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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms, Leslie I. Grad, Justin J. Yerbury, Bradley J. Turner, William C. Guest, Edward Pokrishevsky, Megan A. O'Neill, Anat Yanai, Judith M. Silverman, Rafaa Zeineddine, Lisa Corcoran, Janet Kumita, Leila Luheshi, Masoud Yousefi, Bradley M. Coleman, Andrew Hill, Steven S. Plotkin, Ian R. Mackenzie, and Neil R. Cashman

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Determination of anti-inflammatory activities of standardised preparations of plant- and mushroom-based foods, Dhanushka Gunawardena, Kirubakaran Shanmugam, Suresh Govindaraghavan, Mitchell Low, Louise Bennett, Richard Head, Lezanne Ooi, and Gerald Münch

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A high-dose Shiitake mushroom increases hepatic accumulation of triacylglycerol in rats fed a high-fat diet: underlying mechanism, Dian Handayani, Barbara J. Meyer, Jiezhong Chen, Simon H. J Brown, Todd W. Mitchell, and Xu-Feng Huang

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Dyslipidemia awareness, treatment, control and influence factors among adults in the Jilin province in China: a cross-sectional study, Huan He, Yaqin Yu, Yong Li, Chang Gui Kou, Bo Li, Yuchun Tao, Qing Zhen, Chang Wang, Joseph Sam Kanu, Xu-Feng Huang, Mei Han, and Yawen Liu

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Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats, Meng He, Qingsheng Zhang, Chao Deng, Hongqin Wang, Jiamei Lian, and Xu-Feng Huang

Possible association between DBH 19 bp insertion/deletion polymorphism and clinical symptoms in schizophrenia with tardive dyskinesia, Li Hui, Mei Han, Xu-Feng Huang, Min Jie Ye, Ke Zheng, Jin Cai He, Meng Han Lv, Bao Hua J. Zhang, Jair C. Soares, and Xiang Yang Zhang

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Informal mining in livelihood diversification: mineral dependence and rural communities in Lao PDR, Kuntala Lahiri-Dutt, Kim Alexander, and Chansouk Insouvanh

Betahistine ameliorates olanzapine-induced weight gain through modulation of histaminergic, NPY and AMPK pathways, Jiamei LIAN, Xu-Feng Huang, Nagesh B. Pai, and Chao Deng

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Plasmin(ogen) acquisition by group A Streptococcus protects against C3b-mediated neutrophil killing, Diane Ly, Jude Taylor, James A. Tsatsaronis, Mercedes M. Monteleone, Amanda Skora, Cortny A. Donald, Tracy A. Maddocks, Victor Nizet, Nicholas P. West, Marie Ranson, Mark J. Walker, Jason D. McArthur, and Martina L. Sanderson-Smith

Separate mechanisms for age-related truncation and racemisation of peptide-bound serine, Brian Lyons, Joanne F. Jamie, and Roger J.W Truscott

Characterisation of a novel UV filter in the lens of the thirteen-lined ground squirrel (Ictidomys tridecemlineatus), Brian Lyons, Peter Karuso, Joanne Jamie, Mukoma F. Simpanya, Frank Giblin, and Roger J. W Truscott

Spontaneous cyclization of polypeptides with a penultimate Asp, Asn or isoAsp at the N-terminus and implications for cleavage by aminopeptidase, Brian Lyons, Ann H. Kwan, and Roger J. W Truscott

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Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics, Natalie Matosin, Francesca Fernandez-Enright, Elisabeth Frank, Chao Deng, Jenny Wong, Xu-Feng Huang, and Kelly Newell

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Negativity towards negative results: a discussion of the disconnect between scientific worth and scientific culture, Natalie Matosin, Elisabeth Frank, Martin Engel, Jeremy S. Lum, and Kelly Newell

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A novel population health data source to inform local planning: the SIMLR Study, Darren J. Mayne, Andrew Bonney, Bryan Jones, Lawrence Bott, Stephen Andersen, Peter Caputi, and Donald C. Iverson

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease, Karen E. Murphy, Amanda M. Gysbers, Sarah K. Abbott, Nahid Tayebi, Woojin S. Kim, Ellen Sidransky, Anthony Cooper, Brett Garner, and Glenda M. Halliday

Post-testicular sperm maturation and identification of an epididymal protein in the Japanese quail (Coturnix coturnix japonica), Brett Nixon, Katherine A. Ewen, Klara M. Krivanek, John Clulow, Grahame Kidd, Heath Ecroyd, and Russell C. Jones

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The common acid sphingomyelinase polymorphism p.G508R is associated with self-reported allergy, Martin Reichel, Tanja Richter-Schmidinger, Christiane Muhle, Cosima Rhein, Panagiotis Alexopoulos, Sibylle G. Schwab, Erich Gulbins, and Johannes Kornhuber

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Secretion of acid sphingomyelinase is affected by its polymorphic signal peptide, Cosima Rhein, Martin Reichel, Christiane Muhle, Andrea Rotter, Sibylle G. Schwab, and Johannes Kornhuber

Comparison of tear lipid profile among basal, reflex, and flush tear samples, Athira Rohit, Fiona Stapleton, Simon Brown, Todd W. Mitchell, and Mark D. P Willcox

Effectiveness of individual-focused interventions to prevent chronic disease, Sara Saeed, Mohammad Golfam, Reed Beall, Fred D. Ashbury, Lyle J. Palmer, and Julian Little

A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development, Martina L. Sanderson-Smith, David De Oliveira, Julien Guglielmini, David J. McMillan, Therese Vu, Jessica K. Holien, Anna Henningham, Andrew C. Steer, Debra E. Bessen, James B. Dale, Nigel Curtis, Bernard W. Beall, Mark J. Walker, Michael W. Parker, Jonathan R. Carapetis, Laurence Van Melderen, Kadaba S. Sriprakash, Pierre R. Smeesters, and The M Protein Study Group

Biological insights from 108 schizophrenia-associated genetic loci, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Stephan Ripke, Benjamin M. Neale, Aiden Corvin, James Walters, Kai-How Farh, Peter A. Holmans, Phil Lee, Brendan Bulik-Sullivan, David A. Collier, Hailiang Huang, and Sibylle G. Schwab

Engineering of bismuth oxide nanoparticles to induce differential biochemical activity in malignant and nonmalignant cells, Callum Stewart, Konstantin Konstantinov, Marjorie McDonald, Kathrin Bogusz, Dean Cardillo, Sianne Oktaria, Dongqi Shi, Michael L. F Lerch, Thierry Devers, Stephanie Corde, Anatoly B. Rosenfeld, and Moeava Tehei

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Heme consumption reduces hepatic triglyceride and fatty acid accumulation in a rat model of NAFLD fed westernized diet, Soon Yew Tang, Irwin Kee M. Cheah, Pei Ern Ng, Aina Hoi, and Andrew M. Jenner

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Foods and food components in the Mediterranean diet: supporting overall effects, Linda Tapsell

Polymorphism in casein protein aggregation and amyloid fibril formation, David Thorn, Heath Ecroyd, and John A. Carver

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A female-gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite, Phuong T. Tran, Simon Brown, Todd W. Mitchell, Kai Matuschewski, Paul J. Mcmillan, Kiaran Kirk, Matthew W. A Dixon, and Alexander Maier

Old proteins and the Achilles heel of mass spectrometry. The role of proteomics in the etiology of human cataract, Roger J. W Truscott and Michael Friedrich

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Host responses to group A Streptococcus: cell death and inflammation, James A. Tsatsaronis, Mark J. Walker, and Martina L. Sanderson-Smith

Disease manifestations and pathogenic mechanisms of group A Streptococcus, Mark J. Walker, Timothy Barnett, Jason D. McArthur, Jason Cole, Christine Gillen, Anna Henningham, K S. Sriprakash, Martina L. Sanderson-Smith, and Victor Nizet

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Awareness, treatment, control of diabetes mellitus and the risk factors: survey results from Northeast China, Chang Wang, Yaqin Yu, Xiang Yang Zhang, Yong Li, Chang Gui Kou, Bo Li, Yuchun Tao, Qing Zhen, Huan He, Joseph Sam Kanu, Xu-Feng Huang, Mei Han, and Yawen Liu

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Human protein aging: modification and crosslinking through dehydroalanine and dehydrobutyrine intermediates, Zhen Wang, Brian Lyons, Roger J. W Truscott, and Kevin L. Schey

Serotonintransportergen und stressreagibilität bei unipolarer depression, Hanne Welper, A Aller, Vera Guttenthaler, Susanne Hofels, Leonhard Lennertz, Ute Pfeiffer, Sibylle G. Schwab, and Astrid W. Zobel

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The ratchet effect: dramatic and sustained changes in health care utilization following admission to hospital with chronic disease, David Whyatt, Raji Tenneti, Julie Marsh, Sarah E. Bolt, Anna Kemp, Laura Firth, Kevin Murray, Berwin Turlach, and Alistair Vickery

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The ecological fallacy of the role of age in chronic disease and hospital demand, David Whyatt, Raji Tenneti, Julie Marsh, Anna Kemp, Laura Firth, Kevin Murray, Berwin Turlach, and Alistair Vickery

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Regulation of a TrkB Alternative Transcript by microRNAs, Jenny Wong

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Central inflammation and leptin resistance are attenuated by ginsenoside Rb1 treatment in obese mice fed a high-fat diet, Yizhen Wu, Yinghua Yu, Alexander Szabo, Mei Han, and Xu-Feng Huang

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Effects of olanzapine on the elevation of macrophage infiltration and pro-inflammatory cytokine expression in female rats, Qingsheng Zhang, Meng He, Chao Deng, Hongqin Wang, and Xu-Feng Huang

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Hypothalamic ghrelin signalling mediates olanzapine-induced hyperphagia and weight gain in female rats, Qingsheng Zhang, Meng He, Chao Deng, Hongqin Wang, Jiamei Lian, and Xu-Feng Huang

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Olanzapine reduced brown adipose tissue thermogenesis and locomotor activity in female rats, Qingsheng Zhang, Jiamei Lian, Meng He, Chao Deng, Hongqin Wang, and Xu-Feng Huang

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Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition, Hua Zhao, Kalani Ruberu, Hongyun Li, and Brett Garner

Papers from 2013

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An Improved High-Throughput Lipid Extraction Method for the Analysis of Human Brain Lipids, Sarah K. Abbott, Andrew M. Jenner, Todd W. Mitchell, Simon H. Brown, Glenda M. Halliday, and Brett Garner

Global fatty acid composition is altered in Parkinson's disease anterior cingulate cortex, S K. Abbott, G M. Halliday, and B Garner

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Novel implications of Lingo-1 and its signalling partners in the Dorsolateral prefrontal cortex in schizophrenia, Jessica L. Andrews, Kelly A. Newell, Xu-Feng Huang, and Francesca Fernandez-Enright

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Structural and functional aspects of hetero-oligomers formed by the small heat shock proteins αB-crystallin and HSP27, J Andrew Aquilina, Sudichhya Shrestha, Amie M. Morris, and Heath Ecroyd

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Burden and support needs of carers of persons with borderline personality disorder: a systematic review, Rachel Bailey and Brin F. S Grenyer

Metacognitive Narrative Psychotherapy for people diagnosed with schizophrenia: an outline of a principle-based treatment manual, Rebecca Bargenquast and Robert Schweitzer

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Increased apolipoprotein D dimer formation in Alzheimer's disease hippocampus is associated with lipid conjugated diene levels, Surabhi Bhatia, Andrew M. Jenner, Hongyun Li, Kalani Ruberu, Adena S. Spiro, Claire E. Shepherd, Jillian J. Kril, Nupur Kain, Anthony Don, and Brett Garner

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Men who have sex with men, infectious syphilis and HIV coinfection in inner Sydney: results of enhanced surveillance, Susan J. Botham, Kelly-Anne Ressler, Patrick Maywood, Kirsty G. Hope, Chris P. Bourne, Stephen J. Conaty, Mark J. Ferson, and Darren J. Mayne

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Cerium oxide nanoparticles: influence of the high-Z component revealed on radioresistant 9L cell survival under X-ray irradiation, Adam Briggs, stephanie corde, Sianne Oktaria, Ryan Brown, Anatoly B. Rosenfeld, Michael Lerch, Konstantin Konstantinov, and Moeava Tehei

A comparison of patient matched meibum and tear lipidomes, Simon H. Brown, Carolina M. E Kunnen, Eva Duchoslav, Naveen K. Dolla, Michael J. Kelso, Eric B. Papas, Percy Lazon de la Jara, Mark D.P Willcox, Stephen J. Blanksby, and Todd W. Mitchell

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Benefits, issues, and recommendations for personalized medicine in oncology in Canada, C Butts, S Kamel-Reid, G Batist, S Chia, C Blanke, M Moore, M B. Sawyer, C Desjardins, A Dubois, J Pun, K Bonter, and F D. Ashbury

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Author reply, John Carmody, Victoria Traynor, Don C. Iverson, and Elena M. Marchetti

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Novel behavioural characteristics of the APPSwe/PS1ΔE9 transgenic mouse model of Alzheimer's disease, David Cheng, Warren Logge, Jac Kee Low, Brett Garner, and Tim Karl

Potential value and limitation of dual inhibitors of pi3k and mtor in the treatment of cancer, Jiezhong Chen

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Recent advance in the studies of beta-glucans for cancer therapy, Jiezhong Chen

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The key regulatory roles of the PI3K/Akt signaling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration, Jiezhong Chen, Ross Crawford, Chen Chen, and Yin Xiao

Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis, Jiezhong Chen, Ross Crawford, and Yin Xiao

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Applications of nanotechnology for melanoma treatment, diagnosis, and theranostics, Jiezhong Chen, Renfu Shao, Xu Dong Zhang, and Chen Chen