The Illawarra Health and Medical Research Institute is a partnership between the University of Wollongong and the South Eastern Sydney Illawarra Area Health Service. IHMRI's research focuses on health and medical issues that are common in the Illawarra region and is aimed at improving the health and well being of the local community. IHMRI's goal is to foster research collaboration through the IHMRI Research Network, creating a centre of excellence and innovation that represents the focal point of health and medical research in this region.


Papers from 2013

Metabotropic glutamate receptor 5 in schizophrenia: emerging evidence for the development of antipsychotic drugs, Kelly A. Newell


Proenergetic effects of resveratrol in the murine neuronal cell line Neuro2a, Nhu T.Q Nguyen, Lezanne Ooi, Sabine C. Piller, and Gerald Munch

Development and evaluation of the REACH (Recognise End of life And Care Holistically) out in Dementia toolkit, J. Potter, Ramesh Fernando, and Nancy Humpel

Categorising foods in terms of nutrient content, Yasmine Probst, Linda Tapsell, Rebecca Thorne, and Jane O'Shea


A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection, Martina L. Sanderson-Smith, Yueling Zhang, Diane Ly, Deborah Donahue, Andrew Hollands, Victor Nizet, Marie Ranson, Victoria A. Ploplis, Mark J. Walker, and Francis J. Castellino

Improved GC-MS methods for analysis of homocysteine, methionine and methylmalonate in cultured cells, A S. Spiro, A M. Jenner, and B Garner

Banking human induced pluripotent stem cells: lessons learned from embryonic stem cells?, Glyn N. Stacey, Jeremy M. Crook, Derek Hei, and Tenneille Ludwig


Preventing help-negation for suicidal ideation: Implications for thwarted belongingness, social network size and frequency of social interaction, Alexander Svenson, Coralie J. Wilson, and Peter Caputi

Age-related human nuclear cataract. Blindness due to inexorable protein deterioration, R Truscott

Discovering the cause of human age-related cataract, Roger JW Truscott, Michael Friedrich, Michelle Hooi, and Brian Lyons


Streptococcal collagen-like protein A and general stress protein 24 are immunomodulating virulence factors of group A Streptococcus, James A. Tsatsaronis, Andrew Hollands, Jason N. Cole, Peter G. Maamary, Christine M. Gillen, Nouri L. Ben Zakour, Malak Kotb, Victor Nizet, Scott A. Beatson, Mark J. Walker, and Martina L. Sanderson-Smith


Recent highlights in the development of isatin-based anticancer agents, Kara L. Vine, Lidia Matesic, Julie M. Locke, and Danielle Skropeta


Rapid quantification of free cholesterol in tears using direct insertion/electron ionization-Mass spectrometry, Xiaojia Eric Wei, John Korth, Simon H. J Brown, Todd W. Mitchell, Roger J. W Truscott, Stephen J. Blanksby, Mark D. P Willcox, and Zhenjun Zhao


Cognitive, affective and social processes involved in help-negation after critical suicidal thoughts, Coralie Wilson, Alexander Svenson, and Peter Caputi

Altered expression of RNA splicing proteins in Alzheimer's disease patients: evidence from two microarray studies, Jenny Wong


Neurotrophin signaling and Alzheimer's Disease neurodegeneration - Focus on BDNF/TrkB signaling, Jenny Wong

Expression of NPAS3 in the human cortex and evidence of its posttranscriptional regulation by miR-17 during development, with implications for schizophrenia, Jenny Wong, Carlotta E. Duncan, Natalie J. Beveridge, Maree J. Webster, Murray J. Cairns, and Cynthia Shannon Weickert

Increases in two truncated TrkB isoforms in the prefrontal cortex of people with schizophrenia, Jenny Wong, D A Rothmond, M J Webster, and Cynthia Shannon Weickert


Reduction of histamine h1 receptor binding induced by high-fat diet can be 1 prevented by DHA and dietary fiber in specific brain areas of male rats, Zhixiang Wu, Yinghua Yu, Yizhen Wu, Craig S. Patch, Alexander Szabo, and Xu-Feng Huang

Hyaluronic acid modified mesoporous silica nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells, Meihua Yu, Siddharth Jambhrunkar, Peter Thorn, Jiezhong Chen, Wenyi Gu, and Chengzhong Yu


DHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet, Yinghua Yu, Yizhen Wu, Craig Patch, Zhixiang Wu, Alexander Szabo, Duo Li, and Xu-Feng Huang


Teasaponin reduces inflammation and central leptin resistance in diet-induced obese male mice, Yinghua Yu, Yizhen Wu, Alexander Szabo, Zhixiang Wu, Hongqin Wang, Duo Li, and Xu-Feng Huang

Development of subcellular fractionation techniques to determine the intracellular cobalamin transit in vitro and the impact of lysosomal dysfunction, H Zhao, K R. Ruberu, H Y. Li, and B Garner


Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue, Hua Zhao, Kalani Ruberu, Hongyun Li, and Brett Garner

Papers from 2012


Using a social functionalist framework to understand responses to projected sea level rise and managed retreat policies in Australia, Kim Alexander and Anthony Ryan

Managed retreat of coastal communities: understanding responses to projected sea level rise, Kim S. Alexander, Anthony Ryan, and Thomas G. Measham

Where to draw the line: understanding responses of Australian coastal communities to sea level rise adaptation policies, K S. Alexander, A Ryan, R Gorddard, R Wise, and A Leitch


Proteogenomic analyses of Lingo-1 and the Nogo receptor in schizophrenia, J Andrews, K Newell, and F Fernandez


Recent peritonitis associates with mortality among patients treated with peritoneal dialysis, Neil Boudville, Anna Kemp, Philip Clayton, Wai Lim, Sunil V. Badve, Carmel M. Hawley, Stephen P. McDonald, Kathryn J. Wiggins, Kym M. Bannister, Fiona G. Brown, and David W. Johnson


Factors associated with chronic kidney disease progression in Australian nephrology practices, Neil Boudville, Anna Kemp, Henry Moody, Robert G. Fassett, Eugenie Pedagogos, Craig Nelson, Helen Healy, George Mangos, Geoff Kirkland, Troy Kay, Paul Champion De Crespigny, David Hoffman, and David Waugh

The effect of trauma on expressive language impairment in borderline personality disorder, Phoebe Carter and Brin F. S Grenyer


Ovarian torsion in a 22-year old nulliparous woman, Hsiao-En Cindy Chen and Christos Georgiou


Prevention of obesity-associated colon cancer by (-)-epigallocatechin-3 gallate and curcumin, Jiezhong Chen

A review of cancer registry data in response to concerns about a possible excess of cancer associated with the emissions from the M5 East tunnel, Stephen Conaty, Darren Mayne, Kirsty Hope, and Mark Ferson

Degradation of an old human protein: Age-dependent cleavage of yS-crystallin generates a peptide that binds to cell membranes, Michael G. Friedrich, J Lam, and Roger J. Truscott


Skepticism of de-torting large ovaries, C Georgiou

The possible mechanisms for β-glucans to prevent atherosclerotic lesions, Tiphaine Gislette, Kong-Nan Zhao, Wenyi Gu, and Jiezhong Chen


TNF-α promotes IFN-γ-Induced CD40 expression and antigen process in Myb-transformed hematological cells, Wenyi Gu, Jiezhong Chen, Lei Yang, and Kong-Nan Zhao

A cluster randomised controlled trial of vascular risk factor management in general practice, Mark F. Harris, Mahnaz Fanaian, Upali W. Jayasinghe, Megan Passey, Suzanne H. Mckenzie, G Davies, David Lyle, Rachel A. Laws, Heike Schuetze, and Qing Wan

A bacterial pathogen co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides, Andrew Hollands, D Gonzalez, E Leire, Cortny A. Donald, Richard L. Gallo, Martina L. Sanderson-Smith, P Dorrestein, and Victor Nizet

Racemization of two proteins over our lifespan: deamidation of asparagine 76 in yS crystallin is greater in cataract than in normal lenses across the age range, M Y. Hooi, M Raftery, and Roger J. Truscott


Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells, Iman Jalilian, Mari Spildrejorde, Aine Seavers, Belinda L. Curtis, Jason D. McArthur, and Ronald Sluyter

Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease, Andrew M. Jenner, Guanghou Shui, M. R. Wenk, L. Lim, V. Jackson-Lewis, S. Przedborski, S. Kesavapany, A. X. H. Goh, M. Fivaz, and L. C. Wong


Cognitive phenotyping of amyloid precursor protein transgenic J20 mice, Tim Karl, Surabhi Bhatia, David Cheng, Woojin Scott Kim, and Brett Garner

Have increases in co-payments for medicines further burdened Australians in remote and disadvantaged areas?, Anna Kemp, John Glover, David B. Preen, Max Bulsara, James Semmens, and Elizabeth Roughead

The validity of prescription and other health service claims and self-report in identifying cases of invasive breast cancer in Australia, Anna Kemp, David B. Preen, Kris Rogers, Christobel Saunders, C D'Arcy Holman, Max Bulsara, Fran Boyle, and Elizabeth Roughead

Assessment of alternative water options in Adelaide: the MARSUO and optimal water resource mix projects, R Leonard and K S. Alexander


Distinct neurobehavioural effects of cannabidiol in transmembrane domain neuregulin 1 mutant mice, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Alexander Wong, Adena Spiro, Iain S. McGregor, Jonathon Arnold, and Tim Karl

Software agents in clinical workflow, clinical guidelines and clinical trial medicine, Andrew Alexis Miller and Fiona Hegi-Johnson


Application of the water needs index: Can Tho City, Mekong Delta, Vietnam, Magnus Moglia, Luis E. Neumann, Kim S. Alexander, Mihn N. Nguyen, Ashok K. Sharma, Stephen Cook, Nguyen H. Trung, and Dinh D.A Tuan

Phospholipid peroxidation: Lack of effect of fatty acid pairing, Sarah E. Norris, Todd Mitchell, and Paul L. Else


Genetic modulation of the long-term effects of cannabis on brain structure, function and symptomatology, Nadia Solowij, Francesca Fernandez, Robin Murray, and Murat Yucel


Molecular signatures of long-lived proteins: Autolytic cleavage adjacent to serine residues, Shi-Ping (Jim) Su, Brian Lyons, M G. Friedrich, Jason D. McArthur, Xiuxian Song, D Xavier, Roger J. Truscott, and J A. Aquilina


Are we making the grade? The education of children and young people in out-of-home care, Michelle Townsend

Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine?, Roger J. W Truscott, Jasminka Mizdrak, Michael G. Friedrich, Michelle Y. Hooi, Bryan Lyons, Joanne F. Jamie, Michael J. Davies, Phillip A. Wilmarth, and Larry L. David


Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease, Jenny Wong, Brett Garner, Glenda M. Halliday, and John B.J Kwok


Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer's disease, J Wong, M Higgins, G Halliday, and B Garner

Papers from 2011


Chapter 4: 'Water' - Resource Efficiency in Asia and the Pacific, Kim Alexander and James West

Evaluation of water needs index case studies, K S. Alexander, M Moglia, G Tjandraatmadja, M Nguyen, S Larson, N H. Trung, and R A. Barkey

Scanner uniformity improvements for radiochromic film analysis with matt reflectance backing, Ethan Butson, Hani Alnawaf, Peter K.N Yu, and Martin Butson

A possible role of cIAP2 in Helicobacter pylori-associated gastric cancer, Jiezhong Chen, Zesong Li, Kwok Wah Chan, Liang Qiao, and Benjamin C. Y. Wong

Up-regulation of endoplasmic reticulum stress-related genes during the early phase of treatment of cultured cortical neurons by the proteasomal inhibitor lactacystin, M. Chen, Andrew M. Jenner, Z. F. Peng, A. J. Melendez, N. S. Cheung, J. Manikandan, and M. S. Choy

Dependence on Endocytic Receptor Binding via a Minimal Binding Motif Underlies the Differential Prognostic Profiles of SerpinE1 and SerpinB2 in Cancer, Blake J. Cochran, David Croucher, Sergei A. Lobov, Darren Saunders, and Marie Ranson


Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand, Melissa De Souza, Hayden Matthews, Jodi A. Lee, Marie Ranson, and Michael J. Kelso

Isoform-specific proteolysis of apolipoprotein-E in the brain, David A. Elliott, Kayan Tsoi, Sandra Holinkova, Sharon L. Chan, Woojin S. Kim, Glenda M. Halliday, Kerry-Anne Rye, and Brett Garner

Metformin therapy during pregnancy: good for the goose and good for the gosling too?, Denice S. Feig and Robert G. Moses

The use of health impact assessment to determine the potential impact of an Australian urban development proposal on health and well-being, Susan Furber, Dian Tranter, Ben Harris-Roxas, Carolyn Dews, Erica Gray, Andy Goldie, Cate Wallace, Darren Mayne, and Sarah Thackway

Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation, Brett Garner, A Brown, Hanna Appelqvist, C Nilsson, K Kagedal, and K Ollinger


Mass and relative elution time profiling: Two-dimensional analysis of sphingolipids in Alzheimer's disease brains, Leila Hejazi, Jason Wong, D. Cheng, Nicholas Proschogo, D. Ebrahimi, Brett Garner, and Anthony Don

Chronic resveratrol intake reverses pro-inflammatory cytokine profile and oxidative DNA damage in ageing hybrid mice, Andrew M. Jenner, Runsheng Ruan, Jan Gruber, Francis Eng Hock Tay, and Yee Ting Wong

Nuclear microscopy of rat colon epithelial cells, Andrew M. Jenner, Frank Watt, Reshmi Rajendran, M. Ren, C. Udalagama, A. E. Rodrigues, and M. Ng

Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma, Jodi A. Lee, Blake J. Cochran, Sergei A. Lobov, and Marie Ranson

Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: implications for cellular proteolysis and adhesion in cancer, Sergei Lobov and Marie Ranson

Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty?, Hayden Matthews, Marie Ranson, and Michael J. Kelso


A community outbreak of cryptosporidiosis in Sydney associated with a public swimming facility: a case-control study, Darren J. Mayne, Kelly-Anne Ressler, Diane Smith, Gareth Hockey, Susan J. Botham, and Mark J. Ferson

Discussion of the enabling environments for decentralised water systems, Magnus Moglia, K S. Alexander, and Ashok K. Sharma

Perceived performance of decentralised water systems: a survey approach, Magnus Moglia, Ashok K. Sharma, Kim Alexander, and Aditi Mankad

Editorial: The Plasminogen Activation System in Pathology: Use in Prognosis and Therapy, Marie Ranson

Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development, D Sinclair, M J. Webster, J Wong, and C S. Weickert

Full length TrkB potentiates estrogen receptor alpha mediated transcription suggesting convergence of susceptibility pathways in schizophrenia, Jenny Wong, H G Woon, and Cynthia Shannon Weickert

Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice, Zhi-Qiang Xu, Ying Sun, Hong-Yun Li, Yoon Lim, Jin-Hua Zhong, and Xin-Fu Zhou

Codon usage roles in human papillomavirus, Kongnan Zhao and Jiezhong Chen

Papers from 2010

Water needs assessment: learning to deal with scale, subjectivity and high stakes, Kim S. Alexander, Magnus Moglia, and Craig Miller

Sustainable development in the uplands of lao PDR, Kim Suzanne Alexander, Joanne Millar, and Neil Lipscombe

Community management of onsite wastewater treatment systems- what they want in Mount Gambier, South Australia, K S. Alexander, K J. Levett, and J L. Vanderzalm


Changes in colon gene expression associated with increased colon inflammation in interleukin-10 gene-deficient mice inoculated with Enterococcus species, Matthew P. Barnett, Warren C. McNabb, Adrian L. Cookson, Shuotun Zhu, Marcus Davy, Bianca Knoch, Katie Nones, Alison J. Hodgkinson, and Nicole Roy

Psychotherapists' response to borderline personality disorder: a core conflictual relationship theme analysis, Marianne Bourke and Brin Grenyer

The first author h-index (hfa-index): levelling the field for small and large institute medical and science scholars, Martin Butson and Peter K.N Yu


Hormone induction of gamete release and In-vitro fertilization in the critically endangered corroboree frog, Phillip G. Byrne and A J Silla

Activation of signal pathways and the resistance to anti-EGFR treatment in colorectal cancer, J-Z Chen, Xu-Feng Huang, and Andrew Katsifis

The kynurenine pathway and inflammation in amyotrophic lateral sclerosis, Yiquan Chen, Roger Stankovic, Karen M Cullen, Vincent Meininger, Brett Garner, Sarah Coggan, Ross Grant, Bruce J Brew, and Gilles J Guillemin

Lester Luborsky: a trailblazer in empirical research on psychoanalytic therapy, Paul Crits-Christoph, Jacques Barber, Brin Grenyer, and Louis Diguer


Toward consensus in the analysis of urinary 8-oxo-7,8-dihydro-2′- deoxyguanosine as a noninvasive biomarker of oxidative stress, M D Evans, R Olinski, S Loft, M S Cooke, Jr P Rossner, R Sram, T Henriksen, H E Poulsen, Allan Weimann, A Barbieri, L Sabatini, F Violante, S Kino, T Ochi, K Sakai, M Takeuchi, H Kasai, J H N Meerman, D Gackowski, R Rozalski, A Siomek, Barry Halliwell, Andrew M. Jenner, H Wang, C Cerda, G Saez, S Haghdoost, P Svoboda, C-W Hu, M-R Chao, K-Y Peng, W-C Shih, K-Y Wu, H Orhan, N S Istanbullu, V Mistry, P B Farmer, J Sandhu, R Singh, C Cortez, Y Su, R M Santella, P Lambert, and R Smith

Intraluminal pressure readings during the establishment of a positive 'tamponade test' in the management of postpartum haemorrhage, Christos Georgiou


The possible role of IL-17 in obesity-associated cancer, Tiphaine Gislette and Jiezhong Chen


The heart and soul of change: delivering what works in therapy, second edition (Book Review), B. F. S. Grenyer

The Australian psychology workforce 2: A national profile of psychologists' education, training, specialist qualifications and continuous professional development, Brin Grenyer, R. Mathews, D. D Stokes, and K. Crea

An enriched environment improves sensorimotor function post-ischemic stroke, Heidi Janssen, Julie Bernhardt, Janice M. Collier, Emily S. Sena, Patrick McElduff, John R. Attia, Michael R.P Pollack, David W. Howells, Michael Nilsson, Mike B. Calford, and Neil J. Spratt

The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ε2,ε3 and ε4 knock-in mice, Andrew M. Jenner, W L F Lim, M P E Ng, M R Wenk, G Shui, M J Sharman, S E Gandy, and R N Martins

Changes in cholesterol biosynthetic and transport pathways after excitotoxicity, Ji-Hyun Kim, Jinatta Jittiwat, Wei-Yi Ong, Akhlaq A. Farooqui, and Andrew M. Jenner