Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection

Authors

Diane T. Ly, University of WollongongFollow
Deborah Donahue, University of Notre Dame
Mark J. Walker, University of QueenslandFollow
Victoria A. Ploplis, University of Notre Dame
Jason D. McArthur, University of WollongongFollow
Marie Ranson, University of WollongongFollow
Francis J. Castellino, University of Notre Dame
Martina L. Sanderson-Smith, University of WollongongFollow

RIS ID

135273

Publication Details

Ly, D., Donahue, D., Walker, M. J., Ploplis, V. A., McArthur, J. D., Ranson, M., Castellino, F. J. & Sanderson-Smith, M. L. (2019). Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection. Microbes and Infection: a journal on infectious agents and host defenses, 21 (8-9), 412-417.

Abstract

Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA^−/− mice compared to AlbPLG1 mice. This study suggests that tPA has a limited role in this humanized model of GAS infection, further highlighting the importance of its counterpart uPA in GAS disease.

Grant Number

NHMRC/635218