Year
2021
Degree Name
Doctor of Philosophy
Department
School of Medicine
Abstract
Increased quinolinic acid (QA) has been suggested in various mental disease pathology. Excessive QA is shown to overactivate N-Methyl-D-aspartic acid (NMDA) receptor subunit 2B (NR2B) receptors and is deleterious to the neurons; however, the exact mechanism behind this effect is complex and not fully understood. This thesis aimed to investigate the mechanism of QA-induced neurite impairment.
Recommended Citation
Xie, Yuanyi, The mechanism of quinolinic acid-induced neurite lesions: The role of NR2B, ROS and autophagy, Doctor of Philosophy thesis, School of Medicine, University of Wollongong, 2021. https://ro.uow.edu.au/theses1/1456
FoR codes (2008)
1101 MEDICAL BIOCHEMISTRY AND METABOLOMICS, 1109 NEUROSCIENCES, 1116 MEDICAL PHYSIOLOGY
Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.