Year
2022
Degree Name
Doctor of Philosophy
Department
School of Chemistry and Molecular Bioscience
Abstract
P2X7 is an adenosine 5’-triphosphate (ATP)-gated ion channel that plays many roles in health and disease. P2X7 is present on various cell types, including most immune cells, and its activation on these cells promotes inflammatory and immune responses. As such, P2X7 presents a potential therapeutic target for multiple inflammatory disorders including graft-versus-host disease (GVHD) and amyotrophic lateral sclerosis (ALS). Therefore, the general aim of this thesis was to investigate P2X7 as a therapeutic target in mouse models of these disorders.
Recommended Citation
Cuthbertson, Peter Mark, The P2X7 Receptor in Inflammation and Disease, Doctor of Philosophy thesis, School of Chemistry and Molecular Bioscience, University of Wollongong, 2022. https://ro.uow.edu.au/theses1/1404
FoR codes (2008)
1107 IMMUNOLOGY, 0601 BIOCHEMISTRY AND CELL BIOLOGY, 1112 ONCOLOGY AND CARCINOGENESIS, 1115 PHARMACOLOGY AND PHARMACEUTICAL SCIENCES
Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.