Degree Name

Doctor of Philosophy


School of Chemistry


Carbohydrates have been heavily exploited in the development of new therapeutic agents. Extensively utilized in nuclear medicine, derivatives such as [18F]-FDG (13) have gained broad usage in the diagnosis of malignancies. Displaying high selectivity and favourable pharmacokinetics, carbohydrates have subsequently been incorporated into peptide-based imaging agents, producing diagnostic probes with greatly improved physicochemical properties. The efficient radiolabelling of glycoconjugate-based imaging agents however represents a significant challenge, with many glycoconjugates prone to degradation under current radiolabelling conditions.

FoR codes (2008)

030503 Organic Chemical Synthesis, 030499 Medicinal and Biomolecular Chemistry not elsewhere classified



Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.