Year
2014
Degree Name
Doctor of Philosophy
Department
School of Chemistry
Recommended Citation
Cara, Consulato James, “Clickable” glycoconjugates – a new approach to the synthesis of bioconjugates, Doctor of Philosophy thesis, School of Chemistry, University of Wollongong, 2014. https://ro.uow.edu.au/theses/4313
Abstract
Carbohydrates have been heavily exploited in the development of new therapeutic agents. Extensively utilized in nuclear medicine, derivatives such as [18F]-FDG (13) have gained broad usage in the diagnosis of malignancies. Displaying high selectivity and favourable pharmacokinetics, carbohydrates have subsequently been incorporated into peptide-based imaging agents, producing diagnostic probes with greatly improved physicochemical properties. The efficient radiolabelling of glycoconjugate-based imaging agents however represents a significant challenge, with many glycoconjugates prone to degradation under current radiolabelling conditions.
FoR codes (2008)
030503 Organic Chemical Synthesis, 030499 Medicinal and Biomolecular Chemistry not elsewhere classified
Unless otherwise indicated, the views expressed in this thesis are those of the author and do not necessarily represent the views of the University of Wollongong.