Enhancing metabolite coverage in MALDI-MSI using laser post-ionisation (MALDI-2)

Authors

J. C. McKinnon, University of Wollongong
H. H. Milioli, Garvan Institute of Medical Research
C. A. Purcell, Garvan Institute of Medical Research
C. L. Chaffer, Garvan Institute of Medical Research
B. Wadie, European Molecular Biology Laboratory Heidelberg
T. Alexandrov, European Molecular Biology Laboratory Heidelberg
T. W. Mitchell, University of Wollongong
S. R. Ellis, University of Wollongong

Publication Name

Analytical methods : advancing methods and applications

Abstract

Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) of metabolites can reveal how metabolism is altered throughout heterogeneous tissues. Here negative ion mode MALDI-MSI has been coupled with laser post-ionisation (MALDI-2) and applied to the MSI of low molecular weight (LMW) metabolites (

Open Access Status

This publication is not available as open access

Volume

15

Issue

34

First Page

4311

Last Page

4320