A Laplace transform approach to direct and inverse problems for multi-compartment models

Publication Name

European Journal of Applied Mathematics

Abstract

Multi-compartment models described by systems of linear ordinary differential equations are considered. Catenary models are a particular class where the compartments are arranged in a chain. A unified methodology based on the Laplace transform is utilised to solve direct and inverse problems for multi-compartment models. Explicit formulas for the parameters in a catenary model are obtained in terms of the roots of elementary symmetric polynomials. A method to estimate parameters for a general multi-compartment model is also provided. Results of numerical simulations are presented to illustrate the effectiveness of the approach.

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Link to publisher version (DOI)

http://dx.doi.org/10.1017/S0956792522000055