Title

A novel and unexpected one pot synthesis of pyrrolo[1,2-a]quinolines

Publication Name

Tetrahedron Letters

Abstract

A new low temperature route to pyrrolo[1,2-a]quinolines bearing ester groups in the 5-position is reported. The reaction mechanism was found to depend on the reaction temperature. At low temperatures it is proposed the reaction proceeds though an addition-intramolecular SNAr-elimination pathway. This method should find wider use as it avoids high boiling point solvents and affords compatibility with thermosensitive substrates.

Open Access Status

This publication is not available as open access

Article Number

153794

Funding Sponsor

University of Wollongong

Share

COinS
 

Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.tetlet.2022.153794