Application of a fluorescent H2S probe based on excited-state intramolecular proton transfer for detecting latent mechanism of H2S-induced MCF-7 apoptosis
Publication Name
Future Medicinal Chemistry
Abstract
Background: H2S is the third gas transmitter affecting the growth, reproduction and survival of cancer cells. However, the H2S anticancer and antitumor mechanism still needs to be further studied. Methods: Here, FHS-1 was synthesized utilizing excited-state intramolecular proton transfer to detect H2S in MCF-7 cells, and investigated the effects of varying concentrations NaHS on apoptosis. Results: The study found that FHS-1 detects H2S levels with high selectivity and pH stability and that H2S may regulate apoptosis in MCF-7 cells through the p53/mTOR/STAT3 pathway. Conclusion: Researching the influence of H2S on apoptosis can serve as a theoretical foundation for future research into H2S-related anticancer medicines, and the H2S probe can be used as an effective cancer screening tool.
Open Access Status
This publication is not available as open access
Volume
14
Issue
9
First Page
647
Last Page
663
Funding Number
JSBL201802
Funding Sponsor
Xuzhou Science and Technology Program