Title

A Rare Alder-ene Cycloisomerization of 1,6-Allenynes

Publication Name

Chemistry - A European Journal

Abstract

Thermally induced cycloisomerization reactions of 1,6-allenynes gives α-methylene-γ-lactams via intramolecular Alder-ene reactions. The mechanism is supported by computational and deuterium labelling studies. This thermal, non-radical method enables the discovery of a hitherto unknown route that proceeds via a divergent mechanism distinct from the previous [2+2] cycloisomerization manifold.

Open Access Status

This publication is not available as open access

Funding Number

DP180101332

Funding Sponsor

Australian Research Council

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Link to publisher version (DOI)

http://dx.doi.org/10.1002/chem.202104022