A Rare Alder-ene Cycloisomerization of 1,6-Allenynes
Publication Name
Chemistry - A European Journal
Abstract
Thermally induced cycloisomerization reactions of 1,6-allenynes gives α-methylene-γ-lactams via intramolecular Alder-ene reactions. The mechanism is supported by computational and deuterium labelling studies. This thermal, non-radical method enables the discovery of a hitherto unknown route that proceeds via a divergent mechanism distinct from the previous [2+2] cycloisomerization manifold.
Open Access Status
This publication is not available as open access
Funding Number
DP180101332
Funding Sponsor
Australian Research Council