Daldiniaeschsone a, a rare tricyclic polyketide having a chromone unit fused to a δ-lactone and its symmetrical biphenyl dimer, daldiniaeschsone b, from an endophytic fungus daldinia eschscholtzii sdbr-cmunkc745
Journal of Fungi
Daldiniaeschsone A (1), a rare tricyclic polyketide having a chromone unit fused to a δ-lactone and its symmetrical 6,6'-biphenyl dimer, daldiniaeschsone B (2), together with three known compounds (3−5), were isolated from a plant-derived endophytic fungus, Daldinia eschscholtzii SDBR-CMUNKC745. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and HRESIMS. All compounds showed α-glucosidase inhibitory activity with IC50 values ranging from 0.16−0.85 mM and compound 1 was the best α-glucosidase inhibitory activity (IC50 = 0.16 mM).
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Chiang Mai University