Daldiniaeschsone a, a rare tricyclic polyketide having a chromone unit fused to a δ-lactone and its symmetrical biphenyl dimer, daldiniaeschsone b, from an endophytic fungus daldinia eschscholtzii sdbr-cmunkc745

Authors

Natnicha Wutthiwong, Chiang Mai University
Virayu Suthiphasilp, Mae Fah Luang University
Aknarin Pintatum, Mae Fah Luang University
Nakarin Suwannarach, Chiang Mai University
Jaturong Kumla, Chiang Mai University
Saisamorn Lumyong, Chiang Mai University
Tharakorn Maneerat, Mae Fah Luang University
Rawiwan Charoensup, Luang University
Sarot Cheenpracha, University of Phayao
Thunwadee Limtharakul, Chiang Mai University
Stephen G. Pyne, University of Wollongong
Surat Laphookhieo, Mae Fah Luang University

Publication Name

Journal of Fungi

Abstract

Daldiniaeschsone A (1), a rare tricyclic polyketide having a chromone unit fused to a δ-lactone and its symmetrical 6,6'-biphenyl dimer, daldiniaeschsone B (2), together with three known compounds (3−5), were isolated from a plant-derived endophytic fungus, Daldinia eschscholtzii SDBR-CMUNKC745. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and HRESIMS. All compounds showed α-glucosidase inhibitory activity with IC50 values ranging from 0.16−0.85 mM and compound 1 was the best α-glucosidase inhibitory activity (IC50 = 0.16 mM).

Open Access Status

This publication may be available as open access

Volume

7

Issue

5

Article Number

358

Funding Number

DBG6280007

Funding Sponsor

Chiang Mai University