Coumarins and flavones from the fruit and root extracts of Micromelum integerrimum

Authors

Virayu Suthiphasilp, Mae Fah Luang University
Wisanu Maneerat, Mae Fah Luang University
Raymond J. Andersen, University of British Columbia
Stephen G. Pyne, University of WollongongFollow
Chatchai Muanprasat, Mahidol University
Sawinee Seemakhan, Mahidol University
Suparerk Borwornpinyo, Mahidol University
Surat Laphookhieo, Mae Fah Luang UniversityFollow

RIS ID

131755

Publication Details

Suthiphasilp, V., Maneerat, W., Andersen, R. J., Pyne, S. G., Muanprasat, C., Seemakhan, S., Borwornpinyo, S. & Laphookhieo, S. (2018). Coumarins and flavones from the fruit and root extracts of Micromelum integerrimum. Natural Product Research, Online First 1-6.

Abstract

A phytochemical investigation of the fruit and root extracts of Micromelum integerrimum resulted in the isolation and identification of a new compound, integerravone (1), together with 23 known compounds (2-24). Their structures were characterized by spectroscopic methods as well as comparisons made from the literature. Compounds 2, 3-15, 17-18 and 20-23 were evaluated for their cytotoxicities against the colon cancer cell line, HCT116. All of them were inactive at 50 µM. Most of the phenolic compounds were evaluated for their antioxidant activity using the DPPH assay. Compounds 14 and 22-24 showed antioxidant activity with IC50 values ranging from 24.83-135.05 µM.