Alkaloids and styryllactones from Goniothalamus cheliensis

Authors

Wuttichai Jaidee, Mae Fah Luang University
Raymond J. Andersen, University of British Columbia
Brian O. Patrick, University of British Columbia
Stephen G. Pyne, University of WollongongFollow
Chatchai Muanprasat, Mahidol University
Suparerk Borwornpinyo, Mahidol University
Surat Laphookhieo, Mae Fah Luang UniversityFollow

RIS ID

130963

Publication Details

Jaidee, W., Andersen, R. J., Patrick, B. O., Pyne, S. G., Muanprasat, C., Borwornpinyo, S. & Laphookhieo, S. (2019). Alkaloids and styryllactones from Goniothalamus cheliensis. Phytochemistry, 157 8-20.

Abstract

Eight previously undescribed compounds, including four alkaloids and five styryllactones together with 36 known compounds were isolated from the twig and leaf extracts of Goniothalamus cheliensis. Their structures were elucidated by extensive analysis of their spectroscopic data. The absolute configuration of (−)-(4S,5S,6R,7S,8S)-goniochelienlactone and (−)-(4S,5S,6R,7S,8S)-7-acetylgoniochelienlactone were established from single crystal X-ray analysis using Cu Kα radiation. The absolute configurations of the other related compounds were identified by comparisons of their ECD spectra with those of related known compounds. Most of the isolated compounds were evaluated for their cytotoxicities against human colorectal cancer cells (HCT-116). Griffithazanone A was the most potent with an IC50 value of 2.39 μM.