Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis

Authors

Chiramet Auranwiwat, Chiang Mai University, University of Wollongong
Roonglawan Rattanajak, National Science and Technology Development Agency
Sumalee Kamchonwongpaisan, National Science and Technology Development Agency
Surat Laphookhieo, Mae Fah Luang UniversityFollow
Stephen G. Pyne, University of WollongongFollow
Thunwadee Limtharakul, Chiang Mai University

RIS ID

130197

Publication Details

Auranwiwat, C., Rattanajak, R., Kamchonwongpaisan, S., Laphookhieo, S., Pyne, S. G. & Limtharakul, T. (2018). Four new C-benzyl flavonoids from the fruit of Uvaria cherrevensis. Fitoterapia, 130 198-202.

Abstract

The phytochemical investigation of the fruit extracts of Uvaria cherrevensis led to the isolation and characterization of four new C-benzyl flavonoids; cherrevenones A-D (1-4) together with 11 known compounds. The isolated compounds were characterized using spectroscopic techniques. Compounds 1, 3, 5 and 11 showed moderate inhibitory activities against the P. falciparum strains TM4/8.2 and K1CB1 with IC₅₀ values ranging from 21.0 ± 3.10 - 33.7 ± 7.69 and 21.0 ± 5.44 - 43.5 ± 11.9 μM, respectively. Compounds 1, 2, 5, 10 and 11 exhibited strong cytotoxic activities against KB cells with IC₅₀ values ranging from 0.60 ± 0.17 - 4.91 ± 2.69 μM which were similar to their cytotoxic activities found against Vero cells, except for compound 5, which was non-toxic to Vero cells.