Stimuli-Responsive Cycloaurated “OFF-ON” Switchable Anion Transporters

Authors

Mohamed Fares, University of WollongongFollow
Xin Wu
Deepthi Ramesh
William Lewis
Paul A. Keller, University of WollongongFollow
Ethan Howe
Ricardo Perez-Tomas
Philip Gale

RIS ID

144883

Publication Details

Metwaly, M., Wu, X., Ramesh, D., Lewis, W., Keller, P., Howe, E., Perez-Tomas, R. & Gale, P. (2020). Stimuli-Responsive Cycloaurated “OFF-ON” Switchable Anion Transporters. Angewandte Chemie - International Edition,

Abstract

© 2020 Wiley-VCH GmbH Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are “switched on” in situ in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumors than in healthy tissue and hence this approach offers a strategy to target these systems to tumors.