RIS ID
141683
Abstract
This journal is The Royal Society of Chemistry. Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.
Publication Details
Metwaly, M., McCosker, P., Alsherbiny, M., Willis, A., Clark, T., Neyts, J., Jochmans, D. & Keller, P. (2020). Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a] pyrimidines as potential anti-chikungunya agents. RSC Advances, 10 (9), 5191-5195.