A new secoiridoid glycoside and other constituents from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae)

Authors

Watchara Sangsopha, University of Wollongong
Ratsami Lekphrom
Florian Schevenels
Brendan Byatt, University of WollongongFollow
Stephen G. Pyne, University of WollongongFollow
Nattakarn Sridadom
Kanlayanee Sawanyawisuth

RIS ID

143284

Publication Details

Sangsopha, W., Lekphrom, R., Schevenels, F., Byatt, B., Pyne, S., Sridadom, N. & Sawanyawisuth, K. (2020). A new secoiridoid glycoside and other constituents from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae). Natural Product Research,

Abstract

© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group. A new secoiridoid glycoside, 3’-O-p-trans-coumaroylsweroside (1), together with twenty-nine compounds (2–30), were isolated from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae). Their structures were identified by analysis of mass spectrometric and NMR spectroscopic data. Compounds 2, 4, 6, 11 and 13–15 showed weak to moderate cytotoxicity against cholangiocarcinoma cancer cells lines (KKU-213, KKU-055 and KKU-214). We report the first phytochemical investigation of the roots and flowers of F. fragrans, as only the essential oil of the latter has been investigated.