Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a] pyrimidines as potential anti-chikungunya agents
This journal is The Royal Society of Chemistry. Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.
Metwaly, M., McCosker, P., Alsherbiny, M., Willis, A., Clark, T., Neyts, J., Jochmans, D. & Keller, P. (2020). Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a] pyrimidines as potential anti-chikungunya agents. RSC Advances, 10 (9), 5191-5195.