Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a] pyrimidines as potential anti-chikungunya agents

Authors

Mohamed Fares, University of WollongongFollow
Patrick McCosker, University of WollongongFollow
Muhammad Alsherbiny
Anthony Willis
Timothy Clark
Johan Neyts
Dirk Jochmans
Paul A. Keller, University of WollongongFollow

RIS ID

141683

Publication Details

Metwaly, M., McCosker, P., Alsherbiny, M., Willis, A., Clark, T., Neyts, J., Jochmans, D. & Keller, P. (2020). Regioselective convergent synthesis of 2-arylidene thiazolo[3,2-a] pyrimidines as potential anti-chikungunya agents. RSC Advances, 10 (9), 5191-5195.

Abstract

This journal is The Royal Society of Chemistry. Convergent and convenient regioselective synthesis of novel thiazolo[2,3-a]pyrimidine derivatives was accomplished using the one-pot reaction of 6-ethylthiouracil, bromoacetic acid, anhydrous sodium acetate, acetic anhydride, acetic acid and suitable aldehyde. X-ray crystallographic study reveals the presence of the Z configuration of only one regioisomer confirmed by computational studies as being the most likely isomer present.