(R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities

Authors

Thanika Promchai, Chiang Mai University
Thanaphat Thaima, University of WollongongFollow
Roonglawan Rattanajak, National Science and Technology Development Agency, Thailand, BIOTEC, Pathum Thani 12120, Thailand
Sumalee Kamchonwongpaisan, National Science and Technology Development Agency, Thailand, BIOTEC, Pathum Thani 12120, Thailand
Stephen G. Pyne, University of WollongongFollow
Thunwadee Limtharakul, Chiang Mai University

RIS ID

140846

Publication Details

Promchai, T., Thaima, T., Rattanajak, R., Kamchonwongpaisan, S., Pyne, S. G. & Limtharakul, T. (2019). (R)-3-(8'-Hydroxyfarnesyl)-indole and other chemical constituents from the flowers of Anomianthus dulcis and their antimalarial and cytotoxic activities. Natural Product Research

Abstract

A new farnesylindole, (R)-3-(8'-hydroxyfarnesyl)-indole (1), as a scalemic mixture (33% ee) along with nine known compounds (2-10), including one farnesylindole, three flavanones, three flavone derivatives and two chalcone derivatives were isolated from the methanolic crude extract of the flowers from Anomianthus dulcis. All compounds were purified by appropriate chromatographic techniques and their structures elucidated by spectroscopic methods. Compounds 1, 2 and 8 showed moderate antiplasmodial activities against TM4/8.Two and K1CB1 strains of which compound 2 displayed the best activity with IC50 values of 27.9 ± 2.57 and 21.4 ± 1.68 µM, respectively. In addition, compound 1 also presented modest cytotoxicity against a KB cell line with an IC50 value of 22.3 ± 0.39 µM. None of these compounds showed cytotoxicity against Vero cells.