Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia

Authors

Magdalena Przybyla, University of New South Wales
Claire H. Stevens, University of New South WalesFollow
Julia van der Hoven, University of New South Wales
Anne Harasta, University of New South Wales
Mian Bi, University of New South Wales
Arne Ittner, University of New South Wales
Annika van Hummel, University of New South Wales
John R. Hodges, University of New South Wales
Olivier Piguet, University of New South Wales
Tim Karl, Neuroscience Research AustraliaFollow
Michael Kassiou, University f Sydney
Gary D. Housley, University of New South Wales
Yazi D. Ke, University of New South Wales
Lars M. Ittner, University of New South Wales
Janet van Eersel, University of New South Wales

RIS ID

109249

Publication Details

Przybyla, M., Stevens, C. H., van der Hoven, J., Harasta, A., Bi, M., Ittner, A., van Hummel, A., Hodges, J. R., Piguet, O., Karl, T., Kassiou, M., Housley, G. D., Ke, Y. D., Ittner, L. M. & van Eersel, J. (2016). Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia. Neuroscience Letters, 631 24-29.

Abstract

Frontotemporal dementia (FTD) presents clinically with behavioral changes including disinhibition. Mutations in the tau-encoding MAPT gene identified in familial cases of FTD have been used to generate transgenic mouse models of the human condition. Here, we report behavioral changes in a recently developed P301S mutant tau transgenic mouse, including disinhibition-like behavior in the elevated plus maze and hyperactivity in the open field arena. Furthermore, histological analysis revealed the amygdala as a primary and early site of pathological tau deposition in these mice. Taken together, neuropathological and behavioral changes in P301S tau transgenic mice resemble features of human FTD.