Reduced T helper and B lymphocytes in Parkinson's disease



Publication Details

Stevens, C. H., Rowe, D. B., Morel-Kopp, M., Orr, C., Russell, T., Ranola, M., Ward, C. & Halliday, G. M. (2012). Reduced T helper and B lymphocytes in Parkinson's disease. Journal of Neuroimmunology, 252 (1-2), 95-99.


Gene association with HLA suggests involvement of immune mediated mechanisms in the pathogenesis of Parkinson's disease (PD). Only a small number of studies have found differences between circulating leukocyte populations in PD patients compared to controls, with conflicting results. To clarify whether there is a circulating leukocyte PD phenotype, we assessed the numbers of T, B and natural killer cells, and monocytes and found a small reduction (15-25%) in CD4 + T and CD19 + B cells in PD. These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD.

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