Reduced T helper and B lymphocytes in Parkinson's disease

Authors

Claire H. Stevens, University of New South WalesFollow
Dominic B. Rowe, Macquarie UniversityFollow
Marie Christine Morel-Kopp, Macquarie University
Carolyn Orr, Macquarie University
Tonia Russell, University of New South Wales
Madelaine Ranola, Macquarie University
Christopher Ward, University of Sydney
Glenda M. Halliday, University of New South Wales

RIS ID

107559

Publication Details

Stevens, C. H., Rowe, D. B., Morel-Kopp, M., Orr, C., Russell, T., Ranola, M., Ward, C. & Halliday, G. M. (2012). Reduced T helper and B lymphocytes in Parkinson's disease. Journal of Neuroimmunology, 252 (1-2), 95-99.

Abstract

Gene association with HLA suggests involvement of immune mediated mechanisms in the pathogenesis of Parkinson's disease (PD). Only a small number of studies have found differences between circulating leukocyte populations in PD patients compared to controls, with conflicting results. To clarify whether there is a circulating leukocyte PD phenotype, we assessed the numbers of T, B and natural killer cells, and monocytes and found a small reduction (15-25%) in CD4 + T and CD19 + B cells in PD. These findings suggest some compromise in immune cells in PD and have potential implications for immune function and the progression of PD.