Bioactive glycosides from the African medicinal plant Boerhavia erecta L.

Authors

Ari Satia Nugraha, University of WollongongFollow
Adama Hilou, Universite de Ouagadougou
Nicholas Vandegraaff, Avexa Ltd
David I. Rhodes, University of WollongongFollow
Rachada Haritakun, National Science and Technology Development Agency, Thailand
Paul A. Keller, University of WollongongFollow

RIS ID

98659

Publication Details

Nugraha, A. S., Hilou, A., Vandegraaff, N., Rhodes, D. I., Haritakun, R. & Keller, P. A. (2015). Bioactive glycosides from the African medicinal plant Boerhavia erecta L.. Natural Product Research, 29 (20), 1954-1958.

Abstract

Phytochemical studies of the previously unexplored stem of Boerhavia erecta from Burkina Faso, resulted in the isolation of an unreported glycoside 4, 2,3-dihydroxypropylbenzoate-3-O-β-[4″-methoxy] glucuronide as well as seven known glycosides (1-3, 5-8). The major isolate 5 and 8 indicated a significant inhibition against HIV integrase (IC50 10 and 22 μg/mL, respectively). The extracts and isolates were also tested for anti-malarial activity, but insignificant activity was observed.