Cytotoxic and antimalarial alkaloids from the twigs of Dasymaschalon obtusipetalum

Authors

Atchara Jaidee, Chiang Mai University
Thanika Promchai, Chiang Mai University
Kongkiat Trisuwan, Chiang Mai University
Surat Laphookhieo, Mae Fah Luang University
Roonglawan Rattanajak, National Science and Technology Development Agency
Sumalee Kamchonwongpaisan, National Science and Technology Development Agency
Stephen G. Pyne, University of WollongongFollow
Thunwadee Ritthiwigrom, Chiang Mai UniversityFollow

RIS ID

102124

Publication Details

Jaidee, A., Promchai, T., Trisuwan, K., Laphookhieo, S., Rattanajak, R., Kamchonwongpaisan, S., Pyne, S. G. & Ritthiwigrom, T. (2015). Cytotoxic and antimalarial alkaloids from the twigs of Dasymaschalon obtusipetalum. Natural Product Communications: an international journal for communications and reviews, 10 (7), 1175-1177.

Abstract

One new p-quinonoid aporphine alkaloid, obtusipetadione (1), and eleven known compounds (2-12) were isolated from the acetone extract of the twigs of Dasymaschalon obtusipetalum. Their structures were elucidated by spectroscopic methods. The cytotoxic and antimalarial activities of the isolated compounds were evaluated. Compound 1 showed significant in vitro antiplasmodial activity against the P. falciparum strains TM4 and K1 (multidrug resistant strain) with IC50 values of 2.460.12 and 1.380.99 μg/mL, respectively with no cytotoxicity. Compound 9 had more modest antiplasmodial activity, but significant cytotoxicity.