Cardiovascular and metabolic complications during androgen deprivation: exercise as a potential countermeasure

Authors

Daniel A. Galvao, Edith Cowan University
Dennis R. Taaffe, University of QueenslandFollow
Nigel Spry, University of Western Australia
David Joseph, University of Western Australia
Robert U. Newton, Edith Cowan University

RIS ID

101474

Publication Details

Galvao, D. A., Taaffe, D. R., Spry, N., Joseph, D. & Newton, R. U. (2009). Cardiovascular and metabolic complications during androgen deprivation: exercise as a potential countermeasure. Prostate Cancer and Prostatic Diseases, 12 (3), 233-240.

Abstract

Apart from the well-established adverse musculoskeletal and sexual health effects of androgen deprivation therapy (ADT), evidence is accumulating of substantial ADT-related cardiovascular and metabolic complications, which may impact quality of life and overall survival. In this brief review we discuss (1) the incidence of cardiovascular and metabolic complications during/following ADT from large cohort studies, (2) the increased risk factors for cardiovascular and metabolic disease from cross-sectional and prospective studies and (3) the use of physical exercise as a countermeasure in this new era of ADT-related toxicity. It is clear that exercise has the potential to provide a myriad of benefits to men undergoing ADT that may result in reduced morbidity and mortality, and subsequently improve quality of life.