Cutting the forest to see a single tree?
RIS ID
94203
Abstract
The development of single-molecule tools has significantly impacted the way we think about biochemical processes. Watching a single protein in action allows us to observe kinetic details and rare subpopulations that are hidden in ensemble-averaging techniques. I will discuss here the pros and cons of the single-molecule approach in studying ligand binding in macromolecular systems and how these techniques can be applied to characterize the behavior of large multicomponent biochemical systems.
Publication Details
van Oijen, A. M. (2008). Cutting the forest to see a single tree?. Nature Chemical Biology, 4 (8), 440-443.