Alkaloids from the roots of stichoneuron caudatum and their acetylcholinesterase inhibitory activities

Authors

Rosdayati Alino Ramli, University of WollongongFollow
Wilford Lie, University of WollongongFollow
Stephen G. Pyne, University of WollongongFollow

RIS ID

89835

Publication Details

Ramli, R. A., Lie, W. & Pyne, S. G. (2014). Alkaloids from the roots of stichoneuron caudatum and their acetylcholinesterase inhibitory activities. Journal of Natural Products, 77 (4), 894-901.

Abstract

Four new stichoneurine-type alkaloids, stichoneurines F and G (1-2) and sessilistemonamines E and F (3-4), have been isolated from the root extracts of Stichoneuron caudatum. The structures and relative configurations of these alkaloids have been determined by spectroscopic methods and molecular modeling experiments. Compounds 1-4 were tested for their acetylcholinesterase (AChE) inhibitory activities against human AChE. Compound 3 showed significant inhibitory activity with an IC50 value of 9.1 ± 0.15 μM.