Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

Authors

Cindy S. Ma, University of New South Wales
Gary Y. J Chew, Australian National UniversityFollow
Nicholas Simpson, Australian National University
Archana Priyadarshi, Canberra Hospital
Melanie Wong, Westmead Hospital
Bodo Grimbacher, University College London
David A. Fulcher, Westmead Hospital
Stuart Tangye, University of Technology Sydney
Matthew C. Cook, Australian National University

RIS ID

91473

Publication Details

Ma, C. S., Chew, G. Y. J., Simpson, N., Priyadarshi, A., Wong, M., Grimbacher, B., Fulcher, D. A., Tangye, S. G. & Cook, M. C. (2008). Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. Journal of Experimental Medicine, 205 (7), 1551-1557.

Abstract

Hyper-immunoglobulin E syndrome (HIES) is a primary immune deficiency characterized by abnormal and devastating susceptibility to a narrow spectrum of infections, most commonly Staphylococcus aureus and Candida albicans. Recent investigations have identified mutations in STAT3 in the majority of HIES patients studied. Despite the identification of the genetic cause of HIES, the mechanisms underlying the pathological features of this disease remain to be elucidated. Here, we demonstrate a failure of CD4+ T cells harboring heterozygous STAT3 mutations to generate interleukin 17-secreting (i.e., T helper [Th]17) cells in vivo and in vitro due to a failure to express sufficient levels of the Th17-specific transcriptional regulator retinoid-related orphan receptor γt. Because Th17 cells are enriched for cells with specificities against fungal antigens, our results may explain the pattern of infection susceptibility characteristic of patients with HIES. Furthermore, they underscore the importance of Th17 responses in normal host defense against the common pathogens S. aureus and C. albicans.