linG, a new integron-associated gene cassette encoding a lincosamide nucleotidyltransferase

Authors

Renee S. Levings, University of WollongongFollow
Ruth M. Hall, University of Sydney
Diane Lightfoot, University of Melbourne
Steven P. Djordjevic, NSW Department of Primary Industries

RIS ID

17311

Publication Details

Levings, R. S., Hall, R. M., Lightfoot, D. & Djordjevic, S. P. (2006). linG, a new integron-associated gene cassette encoding a lincosamide nucleotidyltransferase. Antimicrobial Agents and Chemotherapy, 50 (10), 3514-3515.

Abstract

Lincosamide antibiotics include lincomycin, a compound produced by several actinomycetes, and its semisynthetic chlorinated derivative clindamycin. These antibiotics block the peptidyltransferase activity of the 50S subunit of the bacterial ribosome, inhibiting protein synthesis, and are active against most gram-positive cocci and anaerobes. However, they are not generally effective against gram-negative bacilli due to intrinsic resistance.