Progress in research on therapy of ovarian cancer with monoclonal antibodies

Authors

Nan Zhang, University of Wollongong

RIS ID

72015

Publication Details

Zhang, N. (2012). Progress in research on therapy of ovarian cancer with monoclonal antibodies. Zhongguo Shengwuzhipinxue Zazhi / Chinese Journal of Biologicals, 25 (9), 1226-1229.

Abstract

Ovarian cancer is the most lethal gynecological malignancy. One possible treatment strategy that may improve the prognosis of patients is the use of monoclonal antibodies (mAbs) which can selectively target tumor cells expressing tumor-associated antigens, and offer potential benefits such as avoiding the cytotoxic effect of traditional chemotherapy on normal tissues. Based on the promising results of preclinical studies, various mAb are currently being evaluated in patients with ovarian cancer, some of which have already demonstrated favorable clinical outcomes in phase I/II studies. This paper reviews the progress in research on therapy of ovarian cancer with mAbs.