Synthesis of berberine-efflux pump inhibitor hybrid antibacterials

Authors

J. B. BremnerFollow
Michael J. Kelso, University of WollongongFollow

RIS ID

34532

Publication Details

Bremner, J. B. & Kelso, M. J. (2010). Synthesis of berberine-efflux pump inhibitor hybrid antibacterials. Synthetic Communications: an international journal for rapid communication of synthetic organic chem, 40 (23), 3561-3568.

Abstract

This article describes the compact synthesis of two isomeric dual-action hybrid antimicrobials where the 13-position of the antibacterial berberine has been linked via 3′-and 4′-methylene bridges to INF55 (5-nitro-2-phenylindole), an inhibitor of the bacterial NorA multidrug-resistance pump.