New integron-associated gene cassette encoding a trimethoprim-resistant DfrB-type dihydrofolate reductase

Authors

Renee Levings, University of Wollongong
D. Lightfoot, University of Melbourne
Liam Elbourne, University of Sydney
R. M. Hall, University of Sydney
Steven P. Djordjevic

RIS ID

15059

Publication Details

Levings, R., Lightfoot, D., Elbourne, L., Hall, R. & Djordjevic, S. (2006). New integron-associated gene cassette encoding a trimethoprim-resistant DfrB-type dihydrofolate reductase. Antimicrobial Agents and Chemotherapy, 50 (8), 2863-2865.

Abstract

A sixth gene cassette containing a dfrB-type gene, dfrB6, was found in a dfrB6-aadA1 cassette array in class 1 integrons. This array was isolated from several multiply antibiotic-resistant Salmonella enterica serovar Infantis strains that appear to be clonally related. The DfrB6 dihydrofolate reductase conferred resistance to trimethoprim.