Synthesis of polyhydroxylated pyrrolizidine and indolizidine compounds and their glycosidase inhibitory activities

Authors

Thunwadee Ritthiwigrom, University of Wollongong
Robert J. Nash, Phytoquest Limited
Stephen G. Pyne, University of WollongongFollow

RIS ID

34573

Publication Details

Ritthiwigrom, T., Nash, R. J. & Pyne, S. G. (2010). Synthesis of polyhydroxylated pyrrolizidine and indolizidine compounds and their glycosidase inhibitory activities. Tetrahedron, 66 (48), 9340-9347.

Abstract

The synthesis of the natural product 3-epi-casuarine and two tricyclic ether bridged analogues, plus 7-deoxy-3,6-diepi-casuarine, 7-epi-australine, 1-epi-castanospermine and 1,6-diepi-castanospermine is described. The glycosidase inhibitory activities of these compounds, along with that of uniflorine A and other polyhydroxylated pyrrolizidines and indolizidines that we have published before, are reported.