RIS ID
16736
Abstract
The anti-malarial activity of the arenearylpyrimidylmethane (AAPM) class of compounds emerged from database searching of a pharmacophore. A new 2 step synthesis of the AAPM scaffold is reported and subsequent substitution yielded a short synthesis of the lead anti-malarial compound. The presence of atropisomerism in this class of compounds is also reported for the first time.
ChemMedChem_AAPM_Supporting Information.pdf (158 kB)
Experimental Procedures
Experimental Procedures
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Publication Details
This article was originally published as: Yepuri, NR, Haritakul, R, Griffith, R, Leach, SP & Keller, PA, The Synthesis and Testing of Arenearylpyrimidylmethanes (AAPM) as Anti-Malarial Agents, ChemMedchem, 2006, 1(7), 715-717. Copyright 2005 John Wiley & Sons. Journal information available here.