A convenient and efficient synthesis of (S)-lysine and (S)-arginine homologues via olefin cross-metathesis

Authors

Timothy P. Boyle, University of Wollongong
John B. Bremner, University of WollongongFollow
Jonathan A. Coates, Avexa Ltd
Paul A. Keller, University of WollongongFollow
Stephen G. Pyne, University of WollongongFollow

RIS ID

11936

Publication Details

This article was originally published as Boyle, TP, Bremner, JB, Coates, JA, Keller, PA & Pyne, SG, A convenient and efficient synthesis of (S)-lysine and (S)-arginine homologues via olefin cross-metathesis, Tetrahedron, 61(30), 2005, 7271-7276. Original journal article available here

Abstract

A convenient five step synthesis of (S)-homolysine, incorporating a key olefin cross-metathesis step in the chain extension methodology, has been developed, together with a six step related synthesis of a new homologue of arginine, (S)-bishomoarginine.