RIS ID
33495
Abstract
Semisynthesis of the known Stemona alkaloids oxystemofoline (7) and methoxystemofoline (8) has been achieved starting from (11Z)-1′,2′-didehydrostemofoline (6), which confirmed their structures and absolute configurations. The synthesis of (1′R)-hydroxystemofoline (9) helped establish this compound as a natural product from Stemona aphylla. (1′S)- Hydroxystemofoline (10) and a number of related analogues were also prepared. In a TLC bioautographic assay, 9 was found to be the most active acetylcholinesterase inhibitor, but it was not as active as galanthamine.
Grant Number
ARC/DP0879491
Additional Grant Number
Included in
Life Sciences Commons, Physical Sciences and Mathematics Commons, Social and Behavioral Sciences Commons
Publication Details
Sastraruji, K., Sastraruji, T., Pyne, S. G., Ung, A. T., Jatisatienr, A. & Lie, W. (2010). Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues. Journal of Natural Products, 73 (5), 935-941.