Unsuccessful ageing: dramatic changes to the human lens lipidome with age

Authors

Jessica R. Hughes, University of WollongongFollow
Jane Deeley, University of WollongongFollow
Shane Ellis, University of WollongongFollow
Stephen J. Blanksby, University of WollongongFollow
Friedrich Leisch, University of WollongongFollow
Roger J. Truscott, University of WollongongFollow
Todd W. Mitchell, University of WollongongFollow

RIS ID

44691

Publication Details

Hughes, J. R., Deeley, J., Ellis, S., Blanksby, S. J., Leisch, F., Truscott, R. J. & Mitchell, T. W. (2011). Unsuccessful ageing: dramatic changes to the human lens lipidome with age. In Special Issue: 43rd Annual Scientific Congress of the Royal Australian and New Zealand College of Ophthalmologists, 19-22 Nov, Canberra. Clinical & Experimental Ophthalmology, 39 (S1), 79-79.

Abstract

It has been postulated that organelle degradation and loss of metabolic activity in the lens centre result in a lack of protein or lipid turnover. This would have major implications for lens function with age. Previous work into age-related lipid alterations has involved pooling whole human lenses. However, for an accurate comparison of age-related lipid alterations, it is necessary to analyse the lens present from birth, i.e. the nucleus. Accordingly, the aim of this study was to analyse lipid changes to individual human lens nuclear regions with age, and map the lens lipid distribution using highly sensitive analytical tools.