C-FOS expression in central cardiovascular pathways

Authors

Jane B. Minson, Flinders University
Satoshi Suzuki, Flinders University
Ida J. Llewellyn-Smith, Flinders University
Paul M. Pilowsky, Flinders University
Leonard F. Arnolda, Flinders UniversityFollow
John P. Chalmers, Flinders University

RIS ID

109233

Publication Details

Minson, J. B., Suzuki, S., Llewellyn-Smith, I. J., Pilowsky, P. M., Arnolda, L. F. & Chalmers, J. P. (1995). C-FOS expression in central cardiovascular pathways. Clinical and Experimental Hypertension, 17 (1-2), 67-79.

Abstract

Injection of muscimol in the caudal ventrolateral medulla increases blood pressure and stimulates neuronal c-fos expression in the rostral ventral medulla (RVM). The blockade of c-fos expression in the RVM by antisense oligonucleotides attenuates the blood pressure response to this muscimol-induced disinhibition of the RVM and also reduces resting blood pressure. The results suggest that cardiovascular neurons in the RVM express c-fos and that the basal and stimulated expression of the c-fos gene is important in the central regulation of blood pressure.