Neurokinin-1 receptor immunoreactivity in hypotension sensitive sympathetic preganglionic neurons

Authors

Kathleen J. Burman, Flinders University
Douglas J. McKitrick, University of Western Australia
Jane B. Minson, Flinders University
Anais West, Flinders University
Leonard F. Arnolda, Flinders UniversityFollow
Ida J. Llewellyn-Smith, Flinders University

RIS ID

107748

Publication Details

Burman, K. J., McKitrick, D. J., Minson, J. B., West, A., Arnolda, L. F. & Llewellyn-Smith, I. J. (2001). Neurokinin-1 receptor immunoreactivity in hypotension sensitive sympathetic preganglionic neurons. Brain Research, 915 (2), 238-243.

Abstract

Substance P activation of neurokinin-1 (NK1) receptors on spinal sympathetic preganglionic neurons (SPN) influences blood pressure. We identified SPN likely to subserve the baroreceptor reflex and established if these neurons showed NK1 receptor-immunoreactivity. Nitroprusside (NP) infusion or inferior vena cava (IVC) constriction activated similar numbers of SPN. Of these, about 40% were NK1 receptor-immunoreactive after NP infusion, but only about 20% were NK1 receptor-immunoreactive after IVC constriction. The distribution of Fos/NK1 receptor SPN suggested that substance P may preferentially target sympathoadrenal SPN.