The engineering of an orally active conotoxin for the treatment of neuropathic pain

Authors

Richard J. Clark, University of Queensland
Jonas Jensen, University of Queensland
Simon T. Nevin, University of Queensland
Brid P. Callaghan, RMIT University
David J. Adams, University of QueenslandFollow
David J. Craik, University of Queensland

RIS ID

105274

Publication Details

Clark, R. J., Jensen, J., Nevin, S. T., Callaghan, B. P., Adams, D. J. & Craik, D. J. (2010). The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angewandte Chemie International Edition, 49 (37), 6545-6548.

Abstract

From killers to curers: Peptides from cone snail venoms are potential therapeutic agents for the treatment of neuropathic pain. Unfortunately, these peptides suffer from the disadvantage of short biological half-lives and poor activity when taken orally. A new orally active conotoxin was developed to solve these problems.